Calcineurin (CaN)
PPP3CA; PPP3-CA; CCN1; CNA1; CALN; CALNA1; PP2B; PP2-B; Protein Phosphatase 3(formerly 2B),Catalytic Subunit,Alpha Isoformprotein Phosphatase 2B; Calcineurin A Alpha
Calcineurin is responsible for activating the transcription of interleukin 2 (IL-2), that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus (Elidel) and tacrolimus (FK506) - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. Calcineurin is linked to receptors for two brain chemicals, NMDA and dopamine. A MIT experiment with genetically altered mice who could not produce calcineurin showed similar symptoms as in humans with schizophrenia: impairment in working memory, attention deficits, aberrant social behavior and several other abnormalities characteristic of schizophrenia.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Hu01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Hu01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Hu01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Hu01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Hu01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Mu01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Mu01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Mu01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Mu01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Mu01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Ra01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Ra01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Ra01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Ra01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Ra01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Ca01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Ca01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Ca01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Ca01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Ca01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Po01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Po01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Po01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Po01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Po01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Bo01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Bo01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Bo01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Bo01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Bo01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Rb01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Rb01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Rb01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Rb01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Rb01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV509Mo01 | Recombinant Calcineurin (CaN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV509Mo01 | Monoclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IP. |
| PAV509Mo01 | Polyclonal Antibody to Calcineurin (CaN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV509Mo01 | CLIA Kit for Calcineurin (CaN) | CLIA assay for Antigen Detection |
| ELV509Mo01 | ELISA Kit for Calcineurin (CaN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Biochim. Biophys. Acta 1178:117-120(1993) [PubMed] [Europe PMC] [Abstract]
"Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease."
Subst. Use Misuse 45:1809-1826(2010) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 97:14632-14637(2000) [PubMed] [Europe PMC] [Abstract]
"Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]
"Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin."
J. Biol. Chem. 280:12683-12689(2005) [PubMed] [Europe PMC] [Abstract]
"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria."
Proc. Natl. Acad. Sci. U.S.A. 105:15803-15808(2008) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex."
Nature 378:641-644(1995) [PubMed] [Europe PMC] [Abstract]
"Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction."
J. Mol. Biol. 369:1296-1306(2007) [PubMed] [Europe PMC] [Abstract]