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Caldesmon (CALD)

CALD1; CDM; H-CAD; L-CAD; NAG22

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Hu01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Hu01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Hu01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Hu01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Hu01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Mu01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Mu01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Mu01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Mu01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Mu01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Ra01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Ra01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Ra01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Ra01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Ra01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Ca01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Ca01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Ca01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Ca01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Ca01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Po01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Po01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Po01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Po01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Po01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Bo01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Bo01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Bo01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Bo01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Bo01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Rb01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Rb01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Rb01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Rb01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Rb01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV508Mo01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV508Mo01 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
PAV508Mo01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IF.
Assay Kits CLV508Mo01 CLIA Kit for Caldesmon (CALD) CLIA assay for Antigen Detection
ELV508Mo01 ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells."
J. Biol. Chem. 266:16917-16924(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning of cDNAs encoding human caldesmons."
Gene 112:197-204(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the human caldesmon gene."
Proc. Natl. Acad. Sci. U.S.A. 89:12122-12126(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone."
J. Muscle Res. Cell Motil. 14:385-391(1993) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]