Melanoma Associated ME20 (ME20M)
PMEL; GP100; SI; SIL; SILV; Pmel17; Silver Homolog; Premelanosome Protein; Silver Locus Protein Homolog; 95 kDa melanocyte-specific secreted glycoprotein
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Hu01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Hu01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Hu01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Hu01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Hu01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Mu01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Mu01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Mu01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Mu01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Mu01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Ra01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Ra01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Ra01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Ra01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Ra01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Ca01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Ca01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Ca01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Ca01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Ca01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Po01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Po01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Po01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Po01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Po01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Bo01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Bo01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Bo01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Bo01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Bo01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Rb01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Rb01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Rb01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Rb01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Rb01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV502Mo01 | Recombinant Melanoma Associated ME20 (ME20M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV502Mo01 | Monoclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IP. |
| PAV502Mo01 | Polyclonal Antibody to Melanoma Associated ME20 (ME20M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV502Mo01 | CLIA Kit for Melanoma Associated ME20 (ME20M) | CLIA assay for Antigen Detection |
| ELV502Mo01 | ELISA Kit for Melanoma Associated ME20 (ME20M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12."
Proc. Natl. Acad. Sci. U.S.A. 88:9228-9232(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of the gene for the melanoma-associated ME20 antigen."
DNA Cell Biol. 13:87-95(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of the melanocyte lineage-specific antigen gp100."
J. Biol. Chem. 269:20126-20133(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection."
Proc. Natl. Acad. Sci. U.S.A. 91:6458-6462(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus."
J. Invest. Dermatol. 106:24-27(1996) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and FISH mapping of human Pmel 17, the putative silver locus."
Pigment Cell Res. 9:42-48(1996) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats."
J. Invest. Dermatol. 121:821-830(2003) [PubMed] [Europe PMC] [Abstract]
"Pmel17 initiates premelanosome morphogenesis within multivesicular bodies."
Mol. Biol. Cell 12:3451-3464(2001) [PubMed] [Europe PMC] [Abstract]
"Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis."
J. Cell Biol. 161:521-533(2003) [PubMed] [Europe PMC] [Abstract]
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
"Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment."
J. Biol. Chem. 279:28330-28338(2004) [PubMed] [Europe PMC] [Abstract]
"MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes."
J. Biol. Chem. 280:14006-14016(2005) [PubMed] [Europe PMC] [Abstract]
"The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers."
J. Biol. Chem. 281:21198-21208(2006) [PubMed] [Europe PMC] [Abstract]
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
"Premelanosome amyloid-like fibrils are composed of only Golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes."
J. Biol. Chem. 283:2307-2322(2008) [PubMed] [Europe PMC] [Abstract]
"The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis."
Dev. Cell 21:708-721(2011) [PubMed] [Europe PMC] [Abstract]