Activating Transcription Factor 1 (ATF1)
EWS-ATF1; FUS/ATF-1; TREB36; Cyclic AMP-Dependent Transcription Factor
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP(basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.
Activating Transcription Factor 1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Hu01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Hu01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Hu01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Hu01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Hu01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Mu01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Mu01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Mu01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Mu01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Mu01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Ra01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Ra01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Ra01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Ra01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Ra01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Ca01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Ca01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Ca01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Ca01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Ca01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Po01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Po01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Po01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Po01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Po01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Bo01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Bo01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Bo01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Bo01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Bo01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Rb01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Rb01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Rb01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Rb01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Rb01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV487Mo01 | Recombinant Activating Transcription Factor 1 (ATF1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV487Mo01 | Monoclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IP. |
| PAV487Mo01 | Polyclonal Antibody to Activating Transcription Factor 1 (ATF1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV487Mo01 | CLIA Kit for Activating Transcription Factor 1 (ATF1) | CLIA assay for Antigen Detection |
| ELV487Mo01 | ELISA Kit for Activating Transcription Factor 1 (ATF1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
EMBO J. 9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
"The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."
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"Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
Erratum
Genes Dev. 4:682-682(1990)
"Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."
Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
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"Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."
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"Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."
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Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress."
J. Cell Sci. 123:3863-3871(2010) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]