Arachidonate-5-Lipoxygenase (ALOX5)
LOX5; 5-LOX; ALOX-5; 5-LO; 5LPG; LOG5; Lipoxygenase 5
Arachidonate 5-lipoxygenase is a member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.5-ALOX catalyzes oxidation of AA at the 5-position to yield 5-HPETE. 5-LO then converts 5-HPETE to leukotriene A4.5-ALOX is a target for pharmaceutical intervention in CAD.
Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-ALOX is expressed in brain cells and may participate in neuropathologic processes.Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Hu01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Hu01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Hu01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Hu01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Hu01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Mu01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Mu01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Mu01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Mu01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Mu01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Ra01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Ra01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Ra01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Ra01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Ra01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Ca01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Ca01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Ca01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Ca01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Ca01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Po01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Po01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Po01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Po01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Po01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Bo01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Bo01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Bo01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Bo01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Bo01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Rb01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Rb01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Rb01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Rb01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Rb01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV478Mo01 | Recombinant Arachidonate-5-Lipoxygenase (ALOX5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV478Mo01 | Monoclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IP. |
| PAV478Mo01 | Polyclonal Antibody to Arachidonate-5-Lipoxygenase (ALOX5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV478Mo01 | CLIA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | CLIA assay for Antigen Detection |
| ELV478Mo01 | ELISA Kit for Arachidonate-5-Lipoxygenase (ALOX5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of the cDNA for human 5-lipoxygenase."
Proc. Natl. Acad. Sci. U.S.A. 85:416-420(1988) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and amino acid sequence of human 5-lipoxygenase."
Proc. Natl. Acad. Sci. U.S.A. 85:26-30(1988) [PubMed] [Europe PMC] [Abstract]
Erratum
Proc. Natl. Acad. Sci. U.S.A. 85:3406-3406(1988)
"Molecular cloning and amino acid sequence of human 5-lipoxygenase."
Adv. Prostaglandin Thromboxane Leukotriene Res. 19:466-469(1989) [PubMed] [Europe PMC] [Abstract]
"Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products."
FASEB J. 25:1097-1105(2011) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human 5-lipoxygenase gene."
Proc. Natl. Acad. Sci. U.S.A. 86:2587-2591(1989) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human 5-lipoxygenase gene promoter."
Proc. Natl. Acad. Sci. U.S.A. 87:9073-9077(1990) [PubMed] [Europe PMC] [Abstract]
"Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase."
Proc. Natl. Acad. Sci. U.S.A. 84:7393-7397(1987) [PubMed] [Europe PMC] [Abstract]
"Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase."
J. Biol. Chem. 266:22057-22062(1991) [PubMed] [Europe PMC] [Abstract]
"Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase."
Biochem. Biophys. Res. Commun. 182:1482-1490(1992) [PubMed] [Europe PMC] [Abstract]
"5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes."
J. Exp. Med. 178:1935-1946(1993) [PubMed] [Europe PMC] [Abstract]
"Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)."
J. Biol. Chem. 277:14793-14800(2002) [PubMed] [Europe PMC] [Abstract]
"Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523."
J. Biol. Chem. 279:41512-41520(2004) [PubMed] [Europe PMC] [Abstract]
"Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils."
J. Biol. Chem. 281:129-136(2006) [PubMed] [Europe PMC] [Abstract]
"Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein."
Biochem. Biophys. Res. Commun. 381:518-522(2009) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export."
J. Biol. Chem. 284:306-313(2009) [PubMed] [Europe PMC] [Abstract]
"Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102."
Biochem. J. 425:265-274(2010) [PubMed] [Europe PMC] [Abstract]
"The structure of human 5-lipoxygenase."
Science 331:217-219(2011) [PubMed] [Europe PMC] [Abstract]
"Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
Carcinogenesis 25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]