Squamous Cell Carcinoma Antigen 1 (SCCA1)
SERPINB3; T4-A; Serpin Peptidase Inhibitor,Clade B(ovalbumin),Member 3; Serpin B3
Squamous cell carcinoma antigen (SCCA), a member of the serine protease inhibitor (serpin) family, is a subfraction of the tumor associated antigen TA-4, is a glycoprotein, with a molecular weight between 42 to 48 kDa.
Total SCCA in the circulation comprises 2 nearly identical, approximately 45 kDa proteins, SCCA1 and SCCA2. Both proteins are members of the high-molecular weight serine proteinase inhibitor (serpin) family with SCCA1 paradoxically inhibiting lysosomal cysteine proteinases and SCCA2 inhibiting chymotrypsin-like serine proteinases.
Although SCCA1 and SCCA2 are detected in the cytoplasm of normal squamous epithelial cells, neither serpin is detected normally in the serum.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Hu01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Hu01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Hu01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Hu01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Hu01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Mu01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Mu01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Mu01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Mu01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Mu01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Ra01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Ra01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Ra01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Ra01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Ra01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Ca01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Ca01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Ca01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Ca01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Ca01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Po01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Po01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Po01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Po01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Po01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Bo01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Bo01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Bo01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Bo01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Bo01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Rb01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Rb01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Rb01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Rb01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Rb01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV461Mo01 | Recombinant Squamous Cell Carcinoma Antigen 1 (SCCA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV461Mo01 | Monoclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IP. |
| PAV461Mo01 | Polyclonal Antibody to Squamous Cell Carcinoma Antigen 1 (SCCA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV461Mo01 | CLIA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | CLIA assay for Antigen Detection |
| ELV461Mo01 | ELISA Kit for Squamous Cell Carcinoma Antigen 1 (SCCA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Squamous cell carcinoma antigen is a new member of the serine protease inhibitors."
Biochem. Biophys. Res. Commun. 181:51-58(1991) [PubMed] [Europe PMC] [Abstract]
"A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."
Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
"Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."
J. Biol. Chem. 278:46709-46717(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]