Immune Receptor Expressed On Myeloid Cells 1 (IREM1)
CD300f; CD300LF; NKIR; IGSF13; CLM1; CD300 Antigen Like Family Member F; CMRF35-Like Molecule 1; Immunoglobulin superfamily member 13; NK inhibitory receptor
CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells.The predicted 290-amino acid protein shares 32% amino acid identity with CMRF35 (CD300C). It contains a 23-residue signal peptide, a 132-residue extracellular region, a 23-residue transmembrane domain, and a 112-residue cytoplasmic region. The extracellular region has a typical Ig-like domain and an N-linked glycosylation site, and the cytoplasmic region has 2 immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and an ITIM-like motif. Northern blot analysis revealed abundant expression of a 1.9-kb transcript in spleen, peripheral blood leukocytes, and lung, but only weak or no expression in all other tissues examined. RT-PCR analysis detected expression in DCs, monocytes, and monocytic cell lines, but not in T or B cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Hu01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Hu01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Hu01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Hu01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Hu01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Mu01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Mu01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Mu01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Mu01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Mu01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Ra01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Ra01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Ra01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Ra01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Ra01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Ca01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Ca01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Ca01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Ca01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Ca01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Po01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Po01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Po01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Po01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Po01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Bo01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Bo01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Bo01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Bo01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Bo01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Rb01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Rb01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Rb01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Rb01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Rb01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV456Mo01 | Recombinant Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV456Mo01 | Monoclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IP. |
| PAV456Mo01 | Polyclonal Antibody to Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV456Mo01 | CLIA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | CLIA assay for Antigen Detection |
| ELV456Mo01 | ELISA Kit for Immune Receptor Expressed On Myeloid Cells 1 (IREM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes."
Biochem. Biophys. Res. Commun. 319:920-928(2004) [PubMed] [Europe PMC] [Abstract]
"IREM-1 is a novel inhibitory receptor expressed by myeloid cells."
Eur. J. Immunol. 34:3690-3701(2004) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1."
J. Mol. Biol. 367:310-318(2007) [PubMed] [Europe PMC] [Abstract]