Neutrophil Gelatinase Associated Lipocalin (NGAL)

LCN2; p25; Lipocalin 2; Oncogene 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Siderocalin LCN2

SPN	V446
HGNC	6526
MGI	96757
PubMed	19055468
RGD	69408
UniProt	P80188
Wiki	NGAL

NGAL (neutrophil gelatinase-associated lipocalin) belongs to the lipocalin family of proteins. These are typically small secreted proteins characterized by their ability to bind small, hydrophobic molecules in a structurally conserved pocket formed by beta-pleated sheet, to bind to specific cell-surface receptors and to form macromolecular complexes. NGAL has many synonyms: it also known as NL (neutrophil lipocalin,HNL, rat NL), lipocalin, oncogene protein 24p3 or uterocalin (in the mouse) and neu-related lipocalin or 25 kDa alpha 2-microglobulin-related protein6 (in the rat). Rat NGAL consists of a single disulfide-bridged polypeptide chain of 178 amino-acid residues with a calculated molecular mass of 22 kDa, but glycosylation increases its apparent molecular mass to 25 kDa.

Reference

"Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils."
Biochem. Biophys. Res. Commun. 202:1468-1475(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans."
Genomics 45:17-23(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells."
FEBS Lett. 357:255-259(1995) [PubMed] [Europe PMC] [Abstract]

"Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase."
J. Biol. Chem. 268:10425-10432(1993) [PubMed] [Europe PMC] [Abstract]

"A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase."
FEBS Lett. 314:386-388(1992) [PubMed] [Europe PMC] [Abstract]

"An iron delivery pathway mediated by a lipocalin."
Mol. Cell 10:1045-1056(2002) [PubMed] [Europe PMC] [Abstract]

"A proteomic analysis of human bile."
Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R."
EMBO J. 28:866-876(2009) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin."
Biochemistry 39:1935-1941(2000) [PubMed] [Europe PMC] [Abstract]

"The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin."
J. Mol. Biol. 289:139-157(1999) [PubMed] [Europe PMC] [Abstract]

"The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition."
Mol. Cell 10:1033-1043(2002) [PubMed] [Europe PMC] [Abstract]