Activating Transcription Factor 6 (ATF6)

Processed cyclic AMP-dependent transcription factor ATF-6 alpha

SPN	V441
HGNC	791
MGI	1926157
PubMed	10866666
RGD	1305471
UniProt	P18850
Wiki	ATF6

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.Sequence analysis predicted that the 670-amino acid protein contains an N-terminal serine-rich domain and a central DNA-binding domain followed by a leucine zipper sequence. Northern blot analysis revealed expression of a 2.5-kb transcript in HeLa cells and 4.5- and 8.0-kb transcripts in all mouse tissues tested, with the exception of spleen. Immunoblot analysis detected expression of a 90-kD protein in HeLa and COS cell lysates.

Reference

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Mol. Cell. Biol. 17:4957-4966(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors."
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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
Genes Dev. 3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]

Erratum
Genes Dev. 4:682-682(1990)

"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress."
Mol. Biol. Cell 10:3787-3799(1999) [PubMed] [Europe PMC] [Abstract]

"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs."
Mol. Cell 6:1355-1364(2000) [PubMed] [Europe PMC] [Abstract]

"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor."
Cell 107:881-891(2001) [PubMed] [Europe PMC] [Abstract]

"Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response."
Mol. Cell. Biol. 21:1239-1248(2001) [PubMed] [Europe PMC] [Abstract]

"The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis."
Gene 273:1-11(2001) [PubMed] [Europe PMC] [Abstract]

"Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response."
J. Biol. Chem. 279:11354-11363(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1."
Dev. Cell 13:365-376(2007) [PubMed] [Europe PMC] [Abstract]

"A thrombospondin-dependent pathway for a protective ER stress response."
Cell 149:1257-1268(2012) [PubMed] [Europe PMC] [Abstract]