Protease, Serine 12 (PRSS12)

Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like (trypsin-like) or subtilisin-like. In humans, they are responsible for co-ordinating various physiological functions, including digestion, immune response, blood coagulation and reproduction.

PRSS12 is a member of the trypsin family of serine proteases. Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.