Adenylate Cyclase 10, Soluble (ADCY10)
SAC; HCA2; SACI; Sacy; Testicular soluble adenylyl cyclase; Hypercalciuria,Absorptive 2; AH-related protein; Germ cell soluble adenylyl cyclase
Adenylate cyclase type 10 is a protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble in testis but particulate in sperm and other tissues. It is unlike other mammalian adenylyl cyclases because it is insensitive to G protein or forskolin regulation and is directly regulated by bicarbonate. It is localized in the cytoplasm and to organelles and is thought to function as a general bicarbonate sensor throughout the body. It plays an important role in the generation of cAMP in spermatozoa, playing possible roles in sperm capacitation, hypermotility, and/or the acrosome reaction.Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Hu01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Hu01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Hu01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Hu01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Hu01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Mu01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Mu01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Mu01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Mu01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Mu01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Ra01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Ra01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Ra01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Ra01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Ra01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Ca01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Ca01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Ca01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Ca01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Ca01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Po01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Po01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Po01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Po01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Po01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Bo01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Bo01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Bo01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Bo01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Bo01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Rb01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Rb01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Rb01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Rb01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Rb01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV406Mo01 | Recombinant Adenylate Cyclase 10, Soluble (ADCY10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV406Mo01 | Monoclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IP. |
| PAV406Mo01 | Polyclonal Antibody to Adenylate Cyclase 10, Soluble (ADCY10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV406Mo01 | CLIA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | CLIA assay for Antigen Detection |
| ELV406Mo01 | ELISA Kit for Adenylate Cyclase 10, Soluble (ADCY10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase."
J. Biol. Chem. 276:31698-31708(2001) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density."
J. Clin. Endocrinol. Metab. 87:1476-1485(2002) [PubMed] [Europe PMC] [Abstract]
"Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate."
J. Biol. Chem. 278:15922-15926(2003) [PubMed] [Europe PMC] [Abstract]
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains."
FASEB J. 17:82-84(2003) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of the human soluble adenylyl cyclase."
Am. J. Physiol. 288:C1305-C1316(2005) [PubMed] [Europe PMC] [Abstract]
"Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP."
J. Gen. Physiol. 130:99-109(2007) [PubMed] [Europe PMC] [Abstract]