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Immunoglobulin Superfamily, Member 2 (IGSF2)

CD101; V7; EWI-101; Cell surface glycoprotein V7; Glu-Trp-Ile EWI motif-containing protein 101

Sequence analysis predicted that the 1,021-amino acid IGSF2 is a type I integral transmembrane protein that has a 20-amino acid hydrophobic signal sequence, a 934-amino acid extracellular domain, a 25-amino acid transmembrane domain, and a short, highly charged 42-amino acid cytoplasmic domain.

The extracellular portion contains 7 pairs of regularly spaced cysteine residues suggestive of a variable type Ig-like protein. Northern blot analysis revealed strong expression of a 3.6-kb transcript in monocytes, peripheral blood lymphocytes, and lung, and weaker expression in spleen, thymus, and small intestine. An additional minor transcript of 6.4 kb, which may represent an incompletely spliced transcript, was also seen.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Hu01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Hu01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Hu01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Hu01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Hu01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Mu01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Mu01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Mu01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Mu01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Mu01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Ra01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Ra01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Ra01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Ra01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Ra01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Ca01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Ca01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Ca01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Ca01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Ca01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Po01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Po01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Po01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Po01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Po01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Bo01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Bo01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Bo01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Bo01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Bo01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Rb01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Rb01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Rb01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Rb01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Rb01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV402Mo01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV402Mo01 Monoclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
PAV402Mo01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IF.
Assay Kits CLV402Mo01 CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA assay for Antigen Detection
ELV402Mo01 ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene."
J. Immunol. 154:4434-4443(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies."
J. Immunol. 154:4423-4433(1995) [PubMed] [Europe PMC] [Abstract]

"Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism."
J. Immunol. 159:1115-1124(1997) [PubMed] [Europe PMC] [Abstract]

"CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation."
Tissue Antigens 50:439-448(1997) [PubMed] [Europe PMC] [Abstract]

"V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation."
J. Immunol. 161:209-217(1998) [PubMed] [Europe PMC] [Abstract]

"Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production."
Eur. J. Immunol. 30:3132-3139(2000) [PubMed] [Europe PMC] [Abstract]

"CD101 expression by Langerhans cell histiocytosis cells."
Histopathology 36:229-232(2000) [PubMed] [Europe PMC] [Abstract]

"EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."
J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]

"CD4+ CD56+ blastic tumor cells express CD101 molecules."
J. Invest. Dermatol. 124:668-669(2005) [PubMed] [Europe PMC] [Abstract]