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Acetylcholinesterase (AchE)

ARAChE; N-AChE; YT

Acetylcholinesterase is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. It is mainly found at neuromuscular junctions and cholinergic synapses in the central nervous system, where its activity serves to terminate synaptic transmission.

AChE has a very high catalytic activity mdash; each molecule of AChE degrades about 5000 molecules of acetylcholine per second. The choline produced by the action of AChE is recycled mdash; it is transported, through reuptake, back into nerve terminals where it is used to synthesize new acetylcholine molecules.Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Hu01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Hu01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Hu01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Hu01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Hu01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Mu01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Mu01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Mu01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Mu01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Mu01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Ra01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Ra01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Ra01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Ra01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Ra01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Ca01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Ca01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Ca01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Ca01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Ca01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Po01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Po01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Po01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Po01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Po01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Bo01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Bo01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Bo01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Bo01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Bo01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Rb01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Rb01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Rb01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Rb01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Rb01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV387Mo01 Recombinant Acetylcholinesterase (AchE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV387Mo01 Monoclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IP.
PAV387Mo01 Polyclonal Antibody to Acetylcholinesterase (AchE) WB; IHC; ICC; IF.
Assay Kits CLV387Mo01 CLIA Kit for Acetylcholinesterase (AchE) CLIA assay for Antigen Detection
ELV387Mo01 ELISA Kit for Acetylcholinesterase (AchE) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure."
Proc. Natl. Acad. Sci. U.S.A. 87:9688-9692(1990) [PubMed] [Europe PMC] [Abstract]

"Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins."
Exp. Cell Res. 210:268-277(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]

"Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase."
FEBS Lett. 247:279-282(1989) [PubMed] [Europe PMC] [Abstract]

"The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580-->Ala mutant."
J. Biol. Chem. 266:23977-23984(1991) [PubMed] [Europe PMC] [Abstract]

"Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding."
J. Biol. Chem. 267:17640-17648(1992) [PubMed] [Europe PMC] [Abstract]

"Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells."
Neurosci. Res. 42:261-268(2002) [PubMed] [Europe PMC] [Abstract]

"External and internal electrostatic potentials of cholinesterase models."
J. Mol. Graph. Model. 15:318-327(1997) [PubMed] [Europe PMC] [Abstract]

"Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II."
Acta Crystallogr. D 56:1385-1394(2000) [PubMed] [Europe PMC] [Abstract]

"The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix."
EMBO J. 23:4394-4405(2004) [PubMed] [Europe PMC] [Abstract]

"Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation."
J. Med. Chem. 53:4002-4008(2010) [PubMed] [Europe PMC] [Abstract]

"Structures of human acetylcholinesterase in complex with pharmacologically important ligands."
J. Med. Chem. 55:10282-10286(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase."
Biochem. J. 453:393-399(2013) [PubMed] [Europe PMC] [Abstract]

"Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism."
Am. J. Hum. Genet. 52:928-936(1993) [PubMed] [Europe PMC] [Abstract]