Cluster Of Differentiation 109 (CD109)
CPAMD7; p180; r150; Gov platelet alloantigens; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
CD109 is a GPI-linked cell surface antigen expressed by CD34 acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).
CD109 encodes a deduced 1,445-amino acid protein with a predicted molecular mass of approximately 162 kD. The protein contains a cleavable 21 residue N-terminal sequence, 17 potential N-linked glycosylation sites, a GPI anchor site, and a thioester motif characteristic of the alpha-2-macroglobulin (A2M)/complement (AMCOM) family.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Hu01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Hu01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Hu01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Hu01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Hu01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Mu01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Mu01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Mu01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Mu01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Mu01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Ra01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Ra01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Ra01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Ra01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Ra01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Ca01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Ca01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Ca01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Ca01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Ca01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Po01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Po01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Po01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Po01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Po01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Bo01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Bo01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Bo01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Bo01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Bo01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Rb01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Rb01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Rb01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Rb01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Rb01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV376Mo01 | Recombinant Cluster Of Differentiation 109 (CD109) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV376Mo01 | Monoclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IP. |
| PAV376Mo01 | Polyclonal Antibody to Cluster Of Differentiation 109 (CD109) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV376Mo01 | CLIA Kit for Cluster Of Differentiation 109 (CD109) | CLIA assay for Antigen Detection |
| ELV376Mo01 | ELISA Kit for Cluster Of Differentiation 109 (CD109) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins."
Blood 99:1683-1691(2002) [PubMed] [Europe PMC] [Abstract]
"CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family."
Gene 327:171-183(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."
FASEB J. 20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]
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"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens."
Blood 99:1692-1698(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets."
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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]