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Poliovirus Receptor Related Protein 2 (PVRL2)

CD112; HVEB; PRR2; PVRR2; Herpesvirus Entry Mediator B; Herpes virus entry mediator B

Poliovirus receptor-related 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions.

It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Expression of PVR or PVRL2 rendered cells susceptible to enhanced lysis in a DNAM1-dependent manner that was nearly abrogated in the presence of antibody to PVR, PVRL2, or DNAM1.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Hu01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Hu01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Hu01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Hu01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Hu01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Mu01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Mu01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Mu01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Mu01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Mu01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Ra01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Ra01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Ra01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Ra01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Ra01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Ca01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Ca01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Ca01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Ca01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Ca01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Po01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Po01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Po01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Po01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Po01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Bo01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Bo01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Bo01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Bo01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Bo01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Rb01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Rb01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Rb01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Rb01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Rb01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV360Mo01 Recombinant Poliovirus Receptor Related Protein 2 (PVRL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV360Mo01 Monoclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IP.
PAV360Mo01 Polyclonal Antibody to Poliovirus Receptor Related Protein 2 (PVRL2) WB; IHC; ICC; IF.
Assay Kits CLV360Mo01 CLIA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) CLIA assay for Antigen Detection
ELV360Mo01 ELISA Kit for Poliovirus Receptor Related Protein 2 (PVRL2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene."
Gene 159:267-272(1995) [PubMed] [Europe PMC] [Abstract]

"A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus."
Virology 246:179-189(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."
DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]

"Structural features of nectin-2 (HveB) required for herpes simplex virus entry."
J. Virol. 75:11185-11195(2001) [PubMed] [Europe PMC] [Abstract]

"PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."
Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion."
Proc. Natl. Acad. Sci. U.S.A. 109:14836-14840(2012) [PubMed] [Europe PMC] [Abstract]