Poliovirus Receptor Related Protein 3 (PVRL3)
CDw113; CD113; PPR3; PRR3; PVRR3; Nectin-3
Reymond et al. (2000) cloned a full-length cDNA encoding PRR3. The deduced 550-amino acid PRR3 protein has a calculated molecular mass of 55.4 kD and contains an N-terminal hydrophobic leader sequence; an ectodomain containing a V-type Ig domain and 2 C-type Ig domains bracketed by 6 cysteine residues; a hydrophobic transmembrane region; and a long cytoplasmic sequence. PRR3 also has 6 potential N-glycosylation sites. Northern blot analysis revealed PRR3 expression predominantly in placenta and testis, with faint or no expression in other tissues. A major transcript of 2.8 kb and minor transcripts of 9.5, 6.0, and 4.7 kb were detected in placenta. PRR3 was also expressed in mammalian epithelial cell lines. Flow cytometry showed expression of PRR3 at the surface of transfected COS-1 cells.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Hu01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Hu01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Hu01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Hu01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Hu01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Mu01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Mu01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Mu01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Mu01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Mu01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Ra01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Ra01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Ra01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Ra01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Ra01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Ca01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Ca01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Ca01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Ca01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Ca01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Po01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Po01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Po01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Po01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Po01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Bo01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Bo01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Bo01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Bo01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Bo01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Rb01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Rb01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Rb01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Rb01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Rb01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV359Mo01 | Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV359Mo01 | Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IP. |
PAV359Mo01 | Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) | WB; IHC; ICC; IF. | |
Assay Kits | CLV359Mo01 | CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | CLIA assay for Antigen Detection |
ELV359Mo01 | ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin."
Gene 255:347-355(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains."
J. Biol. Chem. 278:31251-31260(2003) [PubMed] [Europe PMC] [Abstract]
"Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3."
J. Cell Biol. 171:165-173(2005) [PubMed] [Europe PMC] [Abstract]
"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]
"Nectin ectodomain structures reveal a canonical adhesive interface."
Nat. Struct. Mol. Biol. 19:906-915(2012) [PubMed] [Europe PMC] [Abstract]