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Poliovirus Receptor Related Protein 3 (PVRL3)

CDw113; CD113; PPR3; PRR3; PVRR3; Nectin-3

Reymond et al. (2000) cloned a full-length cDNA encoding PRR3. The deduced 550-amino acid PRR3 protein has a calculated molecular mass of 55.4 kD and contains an N-terminal hydrophobic leader sequence; an ectodomain containing a V-type Ig domain and 2 C-type Ig domains bracketed by 6 cysteine residues; a hydrophobic transmembrane region; and a long cytoplasmic sequence. PRR3 also has 6 potential N-glycosylation sites. Northern blot analysis revealed PRR3 expression predominantly in placenta and testis, with faint or no expression in other tissues. A major transcript of 2.8 kb and minor transcripts of 9.5, 6.0, and 4.7 kb were detected in placenta. PRR3 was also expressed in mammalian epithelial cell lines. Flow cytometry showed expression of PRR3 at the surface of transfected COS-1 cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Hu01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Hu01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Hu01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Hu01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Hu01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Mu01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Mu01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Mu01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Mu01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Mu01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Ra01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Ra01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Ra01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Ra01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Ra01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Ca01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Ca01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Ca01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Ca01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Ca01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Po01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Po01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Po01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Po01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Po01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Bo01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Bo01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Bo01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Bo01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Bo01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Rb01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Rb01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Rb01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Rb01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Rb01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV359Mo01 Recombinant Poliovirus Receptor Related Protein 3 (PVRL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV359Mo01 Monoclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IP.
PAV359Mo01 Polyclonal Antibody to Poliovirus Receptor Related Protein 3 (PVRL3) WB; IHC; ICC; IF.
Assay Kits CLV359Mo01 CLIA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) CLIA assay for Antigen Detection
ELV359Mo01 ELISA Kit for Poliovirus Receptor Related Protein 3 (PVRL3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin."
Gene 255:347-355(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains."
J. Biol. Chem. 278:31251-31260(2003) [PubMed] [Europe PMC] [Abstract]

"Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3."
J. Cell Biol. 171:165-173(2005) [PubMed] [Europe PMC] [Abstract]

"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]

"Nectin ectodomain structures reveal a canonical adhesive interface."
Nat. Struct. Mol. Biol. 19:906-915(2012) [PubMed] [Europe PMC] [Abstract]