Matrix Gla Protein (MGP)
MGLAP; GIG36; Cell growth-inhibiting gene 36 protein
Matrix gla protein (MGP) is a protein found in numerous body tissues that requires vitamin K for its optimum function. It is present in bone (together with the related vitamin K-dependent protein osteocalcin), as well as in heart, kidney and lung. In bone, its production is increased by vitamin D.
MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, protein C, protein S and protein Z.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Hu01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Hu01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Hu01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Hu01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Hu01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Mu01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Mu01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Mu01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Mu01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Mu01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Ra01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Ra01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Ra01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Ra01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Ra01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Ca01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Ca01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Ca01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Ca01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Ca01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Po01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Po01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Po01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Po01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Po01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Bo01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Bo01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Bo01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Bo01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Bo01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Rb01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Rb01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Rb01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Rb01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Rb01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV357Mo01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV357Mo01 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| PAV357Mo01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV357Mo01 | CLIA Kit for Matrix Gla Protein (MGP) | CLIA assay for Antigen Detection |
| ELV357Mo01 | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene."
J. Biol. Chem. 265:15040-15048(1990) [PubMed] [Europe PMC] [Abstract]
"The cDNA and derived amino acid sequences for human and bovine matrix Gla protein."
Nucleic Acids Res. 16:5213-5213(1988) [PubMed] [Europe PMC] [Abstract]
"Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization."
Oncogene 5:1391-1395(1990) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."
Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
"Carboxyl-terminal proteolytic processing of matrix Gla protein."
J. Biol. Chem. 266:21145-21149(1991) [PubMed] [Europe PMC] [Abstract]
"Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome."
Nat. Genet. 21:142-144(1999) [PubMed] [Europe PMC] [Abstract]