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Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)

HB-EGF; DTR; DTS; DTSF; HEGFL; Diphtheria Toxin Receptor; Proheparin-binding EGF-like growth factor; Diphtheria toxin receptor

  • Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.

  • Diphtheria toxin inhibits protein synthesis in eukaryotic cells by catalyzing inactivation of elongation factor-2 (EF2). Entry of toxin into cells is dependent on binding to the cell surface.

  • Mice and rats are resistant to diphtheria toxin, and the resistance extends to cultured cells. Mouse-human hybrid cells are sensitive to diphtheria toxin. Creagan et al. (1975) showed that sensitivity is determined by human chromosome 5, which presumably carries a gene for a receptor for toxin.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Hu01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Hu01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Hu01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Hu01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Hu01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Mu01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Mu01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Mu01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Mu01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Mu01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Ra01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Ra01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Ra01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Ra01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Ra01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Ca01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Ca01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Ca01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Ca01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Ca01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Po01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Po01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Po01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Po01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Po01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Bo01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Bo01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Bo01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Bo01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Bo01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Rb01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Rb01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Rb01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Rb01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Rb01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV355Mo01 Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV355Mo01 Monoclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IP.
PAV355Mo01 Polyclonal Antibody to Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) WB; IHC; ICC; IF.
Assay Kits CLV355Mo01 CLIA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) CLIA assay for Antigen Detection
ELV355Mo01 ELISA Kit for Heparin Binding Epidermal Growth Factor Like Growth Factor (HBEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF."
Science 251:936-939(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein."
J. Biol. Chem. 267:6205-6212(1992) [PubMed] [Europe PMC] [Abstract]

"Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity."
J. Biol. Chem. 270:1015-1019(1995) [PubMed] [Europe PMC] [Abstract]

"Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."
EMBO J. 16:1268-1278(1997) [PubMed] [Europe PMC] [Abstract]

"ErbB and HB-EGF signaling in heart development and function."
Cell Struct. Funct. 31:1-14(2006) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor."
Mol. Cell 1:67-78(1997) [PubMed] [Europe PMC] [Abstract]