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Amylase Alpha 1, Salivary (AMY1)

AMY1A; AMY1B; AMY1C; Ptyalin; 1,4-alpha-D-glucan glucanohydrolase 1

The alpha-amylases hydrolyze alpha-1,4-glucoside bonds in polymers of glucose units. Kamaryt and Laxova  found 2 amylase isoenzymes in serum, one produced by the salivary gland and the second by the pancreas. In 11 of 120 children, a duplication of pancreatic enzyme band was found on starch gel electrophoresis and in each case 1 parent also showed the duplication. In the mouse the salivary and pancreatic amylases are determined by genes at closely linked loci.

The separate loci in the human were designated AMY1 (salivary) and AMY2 (pancreatic). Polymorphism of both the salivary and the pancreatic serum amylases has been demonstrated in man. Ward et al. (1971) studied amylase in saliva and identified electrophoretic variants.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Hu01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Hu01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Hu01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Hu01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Hu01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Mu01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Mu01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Mu01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Mu01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Mu01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Ra01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Ra01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Ra01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Ra01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Ra01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Ca01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Ca01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Ca01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Ca01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Ca01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Po01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Po01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Po01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Po01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Po01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Bo01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Bo01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Bo01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Bo01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Bo01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Rb01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Rb01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Rb01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Rb01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Rb01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV352Mo01 Recombinant Amylase Alpha 1, Salivary (AMY1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV352Mo01 Monoclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IP.
PAV352Mo01 Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1) WB; IHC; ICC; IF.
Assay Kits CLV352Mo01 CLIA Kit for Amylase Alpha 1, Salivary (AMY1) CLIA assay for Antigen Detection
ELV352Mo01 ELISA Kit for Amylase Alpha 1, Salivary (AMY1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Primary structure of human salivary alpha-amylase gene."
Gene 41:299-304(1986) [PubMed] [Europe PMC] [Abstract]

"Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases."
Gene 28:263-270(1984) [PubMed] [Europe PMC] [Abstract]

Erratum
Gene 50:371-372(1986)

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Concerted evolution of human amylase genes."
Mol. Cell. Biol. 8:1197-1205(1988) [PubMed] [Europe PMC] [Abstract]

"Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1."
Mol. Biol. Med. 4:145-155(1987) [PubMed] [Europe PMC] [Abstract]

"Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase."
Electrophoresis 12:74-79(1991) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Structure of human salivary alpha-amylase at 1.6-A resolution: implications for its role in the oral cavity."
Acta Crystallogr. D 52:435-446(1996) [PubMed] [Europe PMC] [Abstract]

"Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase."
J. Mol. Biol. 325:1061-1076(2003) [PubMed] [Europe PMC] [Abstract]