Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra)
CDw116; CD116; CSF2R-A; GM-CSFR; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GMCSFR; GMR; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
The granulocyte macrophage colony-stimulating factor receptor is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.
The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits，an alpha chain, and a beta chain which is also present in the receptors for IL-3 and IL-5. The alpha subunit contains a binding site for granulocyte macrophage colony-stimulating factor. The beta chain is involved in signal transduction. Association of the alpha and beta subunits results in receptor activation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Hu01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Hu01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Hu01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Hu01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Hu01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Mu01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Mu01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Mu01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Mu01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Mu01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Ra01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Ra01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Ra01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Ra01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Ra01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Ca01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Ca01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Ca01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Ca01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Ca01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Po01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Po01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Po01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Po01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Po01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Bo01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Bo01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Bo01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Bo01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Bo01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Rb01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Rb01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Rb01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Rb01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Rb01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV347Mo01 | Recombinant Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV347Mo01 | Monoclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IP. |
| PAV347Mo01 | Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV347Mo01 | CLIA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | CLIA assay for Antigen Detection |
| ELV347Mo01 | ELISA Kit for Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor."
EMBO J. 8:3667-3676(1989) [PubMed] [Europe PMC] [Abstract]
"Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily."
J. Biol. Chem. 269:10905-10912(1994) [PubMed] [Europe PMC] [Abstract]
"A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain."
Proc. Natl. Acad. Sci. U.S.A. 88:7744-7748(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning of a potentially soluble receptor for human GM-CSF."
Nucleic Acids Res. 18:7178-7178(1990) [PubMed] [Europe PMC] [Abstract]
"Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor."
Proc. Natl. Acad. Sci. U.S.A. 88:8203-8207(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor."
Biochim. Biophys. Acta 1223:306-308(1994) [PubMed] [Europe PMC] [Abstract]
"Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit."
Exp. Hematol. 35:1483-1494(2007) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region."
Genomics 14:455-461(1992) [PubMed] [Europe PMC] [Abstract]
"Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1."
J. Exp. Med. 205:2711-2716(2008) [PubMed] [Europe PMC] [Abstract]
"The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation."
Cell 134:496-507(2008) [PubMed] [Europe PMC] [Abstract]
"Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA."
J. Exp. Med. 205:2703-2710(2008) [PubMed] [Europe PMC] [Abstract]