Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2)
CHR-NB2; CHRN-B2; EFNL3; NAChRB2; N-AChR-B2; N-AChRB2; Neuronal Acetylcholine Receptor Beta 2
CHRNB2 encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.the CHRNB2 gene comprises 6 exons and spans approximately 9 kb of genomic DNA from the ATG start codon to the TGA stop codon. Exon 1 contains the 5-prime untranslated region, the ATG start codon, and parts of the sequence coding for the putative signal peptide. The hydrophobic transmembrane domains I through III are located in the large exon 5. Exon 6 contains the transmembrane domain IV as well as the translation stop codon and the 3-prime untranslated region. The CHRNB2 introns vary in size from 150 bp (intron 2) to 4.5 kb (intron 5). The splicing at the junctions of CHRNB2 introns 2, 3, and 5 occurred between codons (splicing type 0).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Hu01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Hu01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Hu01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Hu01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Hu01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Mu01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Mu01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Mu01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Mu01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Mu01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Ra01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Ra01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Ra01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Ra01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Ra01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Ca01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Ca01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Ca01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Ca01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Ca01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Po01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Po01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Po01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Po01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Po01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Bo01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Bo01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Bo01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Bo01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Bo01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Rb01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Rb01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Rb01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Rb01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Rb01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV321Mo01 | Recombinant Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV321Mo01 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IP. |
| PAV321Mo01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV321Mo01 | CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | CLIA assay for Antigen Detection |
| ELV321Mo01 | ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 2 (CHRNb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene."
Nucleic Acids Res. 18:4272-4272(1990) [PubMed] [Europe PMC] [Abstract]
"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
Hum. Genet. 103:645-653(1998) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes."
Mamm. Genome 10:900-905(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
"NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit."
Biochim. Biophys. Acta 1798:1608-1614(2010) [PubMed] [Europe PMC] [Abstract]
"NMR structures of the transmembrane domains of the alpha4beta2 nAChR."
Biochim. Biophys. Acta 1818:1261-1268(2012) [PubMed] [Europe PMC] [Abstract]
"The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy."
Nat. Genet. 26:275-276(2000) [PubMed] [Europe PMC] [Abstract]
"CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy."
Am. J. Hum. Genet. 68:225-231(2001) [PubMed] [Europe PMC] [Abstract]
"Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)."
Nicotine Tob. Res. 4:115-125(2002) [PubMed] [Europe PMC] [Abstract]