Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4)
CD134; TNFRSF4; ACT35; OX40; TXGP1L; TAX transcriptionally-activated glycoprotein 1 receptor
CD134 is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naive T cells, unlike CD28. OX40 is a secondary costimulatory molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels.
OX40 has no effect on the proliferative abilities of CD4 cells for the first three days, however after this time proliferation begins to slow and cells die at a greater rate, due to an inability to maintain a high level of PKB activity and expression of Bcl-2, Bcl-XL and survivin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Hu01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Hu01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Hu01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Hu01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Hu01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Mu01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Mu01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Mu01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Mu01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Mu01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Ra01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Ra01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Ra01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Ra01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Ra01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Ca01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Ca01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Ca01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Ca01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Ca01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Po01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Po01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Po01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Po01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Po01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Bo01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Bo01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Bo01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Bo01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Bo01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Rb01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Rb01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Rb01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Rb01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Rb01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV315Mo01 | Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV315Mo01 | Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IP. |
| PAV315Mo01 | Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV315Mo01 | CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | CLIA assay for Antigen Detection |
| ELV315Mo01 | ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen."
Eur. J. Immunol. 24:677-683(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of OX40 ligand and preliminary characterization of its activities on OX40 receptor."
Circ. Shock 44:30-34(1994) [PubMed] [Europe PMC] [Abstract]
"The HTLV-I protein transcriptionally modulates OX40 antigen expression."
J. Immunol. 165:263-270(2000) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB."
Mol. Cell. Biol. 18:558-565(1998) [PubMed] [Europe PMC] [Abstract]
"Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation."
J. Biol. Chem. 273:5808-5814(1998) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of the costimulatory OX40-OX40L complex."
Structure 14:1321-1330(2006) [PubMed] [Europe PMC] [Abstract]
"Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood."
J. Exp. Med. 210:1743-1759(2013) [PubMed] [Europe PMC] [Abstract]