Cystathionine Gamma Lyase (CSE)
CTH; Cystathionase; Cysteine-protein sulfhydrase; Gamma-cystathionase
CSE is an enzyme which breaks down cystathionine into cysteine and alpha-ketobutyrate. Pyridoxal phosphate is a prosthetic group of this enzyme.The bioavailability of cysteine is rate-limiting for the hepatic synthesis of glutathione. Cysteine is provided through either the diet or the transsulfuration pathway, in which cystathionine derived from methionine is transformed into cysteine by cystathionine gamma-lyase.Mutant mice lacking CTH displayed pronounced hypertension and diminished endothelium-dependent vasorelaxation. Cystathionine was physiologically activated by calcium and calmodulin , which is a mechanism for H2S formation in response to vascular activation. Yang et al. (2008) concluded that their findings provided direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Hu01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Hu01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Hu01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Hu01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Hu01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Mu01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Mu01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Mu01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Mu01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Mu01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Ra01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Ra01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Ra01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Ra01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Ra01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Ca01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Ca01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Ca01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Ca01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Ca01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Po01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Po01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Po01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Po01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Po01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Bo01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Bo01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Bo01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Bo01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Bo01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Rb01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Rb01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Rb01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Rb01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Rb01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV296Mo01 | Recombinant Cystathionine Gamma Lyase (CSE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV296Mo01 | Monoclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IP. |
| PAV296Mo01 | Polyclonal Antibody to Cystathionine Gamma Lyase (CSE) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV296Mo01 | CLIA Kit for Cystathionine Gamma Lyase (CSE) | CLIA assay for Antigen Detection |
| ELV296Mo01 | ELISA Kit for Cystathionine Gamma Lyase (CSE) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase."
Biochem. Biophys. Res. Commun. 189:749-758(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration."
J. Biol. Chem. 274:12675-12684(1999) [PubMed] [Europe PMC] [Abstract]
"H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia."
J. Biol. Chem. 284:11601-11612(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response."
Sci. Signal. 4:RA86-RA86(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S."
J. Biol. Chem. 284:3076-3085(2009) [PubMed] [Europe PMC] [Abstract]
"Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)."
Hum. Genet. 112:404-408(2003) [PubMed] [Europe PMC] [Abstract]
"Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase."
Biochemistry 47:6226-6232(2008) [PubMed] [Europe PMC] [Abstract]