Serum Amyloid P Component (SAP)

APCS; PTX2; Pentaxin-Related; 9.5S Alpha-1-Glycoprotein

SPN	V295
HGNC	584
MGI	98229
PubMed	22337829
RGD	68322
UniProt	P02743
Wiki	SAP

• SAP can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. It is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
  

• SAP is a member of the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened beta-jellyroll structure similar to that of the legume lectins. The name "pentraxin" is derived from the Greek word for five (penta) and berries (ragos) relating to the radial symmetry of five monomers forming a ring approximately 95 Aring across and 35 Aring deep. Human SAP has 51% sequence homology with C-reactive protein (CRP), a classical acute phase response plasma protein, and is a more distant relative to the "long" pentraxins such as PTX3 (a cytockine modulated molecule) and several neuronal pentraxins. Both SAP and CRP are evolutionary conserved in all vertebrates and also found in distant invertebrates such as the horseshoe crab (Limulus polyphemus).

Reference

"Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1."
J. Biol. Chem. 260:7752-7756(1985) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component."
J. Biochem. 100:849-858(1986) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis."
J. Biol. Chem. 260:12895-12898(1985) [PubMed] [Europe PMC] [Abstract]

"Human plasma P component: isolation and characterization."
Biochemistry 17:4304-4311(1978) [PubMed] [Europe PMC] [Abstract]

"Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure."
Proc. Natl. Acad. Sci. U.S.A. 91:5602-5606(1994) [PubMed] [Europe PMC] [Abstract]

"Proteomic characterization of novel serum amyloid P component variants from human plasma and urine."
Proteomics 4:1825-1829(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of pentameric human serum amyloid P component."
Nature 367:338-345(1994) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP."
J. Mol. Biol. 269:570-578(1997) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]