Call Now

Mannose Receptor C Type 1 (MRC1)

CD206; CLEC13D, CLEC13DL, MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1

The mannose receptor found on macrophages and on endothelial cells of the liver is the only known example of a C-type lectin that contains multiple C-type CRDs. One function of the receptor is to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi, so that they can be neutralized by phagocytic engulfment.

Kim et al. characterized the gene for the human macrophage mannose receptor (MRC1) by isolation of clones covering the entire coding region. MRC1 was demonstrated to be divided into 30 exons. The first 3 exons encode the signal sequence, the NH2-terminal cysteine-rich domain, and the fibronectin type II repeat, while the final exon encodes the transmembrane anchor and the cytoplasmic tail.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Hu01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Hu01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Hu01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Hu01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Hu01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Mu01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Mu01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Mu01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Mu01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Mu01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Ra01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Ra01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Ra01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Ra01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Ra01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Ca01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Ca01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Ca01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Ca01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Ca01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Po01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Po01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Po01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Po01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Po01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Bo01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Bo01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Bo01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Bo01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Bo01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Rb01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Rb01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Rb01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Rb01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Rb01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV292Mo01 Recombinant Mannose Receptor C Type 1 (MRC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV292Mo01 Monoclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IP.
PAV292Mo01 Polyclonal Antibody to Mannose Receptor C Type 1 (MRC1) WB; IHC; ICC; IF.
Assay Kits CLV292Mo01 CLIA Kit for Mannose Receptor C Type 1 (MRC1) CLIA assay for Antigen Detection
ELV292Mo01 ELISA Kit for Mannose Receptor C Type 1 (MRC1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains."
J. Biol. Chem. 265:12156-12162(1990) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells."
J. Exp. Med. 172:1785-1794(1990) [PubMed] [Europe PMC] [Abstract]

"Organization of the gene encoding the human macrophage mannose receptor (MRC1)."
Genomics 14:721-727(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor."
J. Biol. Chem. 267:1719-1726(1992) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor."
J. Biol. Chem. 275:21539-21548(2000) [PubMed] [Europe PMC] [Abstract]

"Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility."
Hum. Genet. 127:337-348(2010) [PubMed] [Europe PMC] [Abstract]