Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4)

CD158I; KIR1D; KIR412; KKA3; NKAT8; PAX; Cl-39; Natural killer-associated transcript 8; CD158 antigen-like family member I; NK receptor CL-39/CL-17

SPN	V271
HGNC	6336
PubMed	17257315
UniProt	P43632
Wiki	KIR2DS4

Using primers known to amplify HLA-C-specific NK receptors to screen clones with NK triggering activity, Bottino et al. (1996) also isolated a KIR2DS4 cDNA, which they termed KKA3. Sequence analysis revealed that KIR2DS4 encodes a deduced 304-amino acid protein with an extracellular domain similar to that of KIR2D p58 receptors; however, in the transmembrane region, there is a charged lysine residue, and the cytoplasmic tail has only 39 amino acids with no ITIM (immunoreceptor tyrosine-based inhibitory motif). KIRs with short cytoplasmic tails are associated with NK cell triggering rather than inhibition. Immunoprecipitation analysis showed that KIR2DS4 is expressed in 2 forms, one of 35 to 45 kD and the other of 55 to 58 kD. Flow cytometry analysis showed that KIR2DS4, unlike KIR2DS1 and KIR2DS2, was expressed in only a minority of individuals tested.

Reference

"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]

"Alternatively spliced forms of human killer inhibitory receptors."
Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]

"A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation."
Eur. J. Immunol. 26:1816-1824(1996) [PubMed] [Europe PMC] [Abstract]

"Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes."
J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C."
J. Exp. Med. 206:2557-2572(2009) [PubMed] [Europe PMC] [Abstract]