Granulocyte Chemotactic Protein 2 (GCP2)
CXCL6; SCYB6; GCP2; CKA-3; Chemokine(C-X-C-Motif)ligand 6; Small Inducible Cytokine Subfamily B(Cys-X-Cys)Member 6; Chemokine alpha 3; Small-inducible cytokine B6
Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
The GCP2 gene encodes a propeptide of 114 amino acids. Despite 85% identity of the first 270 nucleotides 5-prime of the transcription start sites, GCP2 and the other CXC chemokine gene ENA78 showed cell-specific differences in regulation.In vivo studies in rabbit demonstrated that GCP2 is a potent inflammatory mediator.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Hu01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Hu01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Hu01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Hu01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Hu01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Mu01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Mu01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Mu01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Mu01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Mu01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Ra01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Ra01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Ra01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Ra01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Ra01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Ca01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Ca01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Ca01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Ca01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Ca01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Po01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Po01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Po01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Po01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Po01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Bo01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Bo01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Bo01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Bo01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Bo01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Rb01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Rb01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Rb01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Rb01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Rb01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV265Mo01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV265Mo01 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
PAV265Mo01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
Assay Kits | CLV265Mo01 | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA assay for Antigen Detection |
ELV265Mo01 | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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"Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
"The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."
Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]