Call Now

Integrin Beta 2 (ITGb2)

CD18; ITG-B2; LAD; LFA1; MAC1; LCAMB; MF17; LFAb; Complement Component 3 Receptor 3 And 4 Subunit; Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1

The ITGB2 is a protein belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1.

Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Hu01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Hu01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Hu01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Hu01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Hu01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Mu01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Mu01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Mu01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Mu01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Mu01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Ra01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Ra01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Ra01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Ra01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Ra01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Ca01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Ca01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Ca01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Ca01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Ca01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Po01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Po01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Po01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Po01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Po01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Bo01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Bo01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Bo01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Bo01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Bo01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Rb01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Rb01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Rb01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Rb01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Rb01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV249Mo01 Recombinant Integrin Beta 2 (ITGb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV249Mo01 Monoclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IP.
PAV249Mo01 Polyclonal Antibody to Integrin Beta 2 (ITGb2) WB; IHC; ICC; IF.
Assay Kits CLV249Mo01 CLIA Kit for Integrin Beta 2 (ITGb2) CLIA assay for Antigen Detection
ELV249Mo01 ELISA Kit for Integrin Beta 2 (ITGb2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family."
Cell 48:681-690(1987) [PubMed] [Europe PMC] [Abstract]

"The gene organisation of the human beta 2 integrin subunit (CD18)."
FEBS Lett. 294:97-103(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor."
EMBO J. 6:915-919(1987) [PubMed] [Europe PMC] [Abstract]

"Familial genetic defect in a case of leukocyte adhesion deficiency."
Hum. Mutat. 2:458-467(1993) [PubMed] [Europe PMC] [Abstract]

"Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins."
J. Biol. Chem. 267:3351-3357(1992) [PubMed] [Europe PMC] [Abstract]

"Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity."
Nature 404:617-621(2000) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes."
J. Biol. Chem. 277:1728-1738(2002) [PubMed] [Europe PMC] [Abstract]

"RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1."
J. Biol. Chem. 279:13027-13034(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins."
Nat. Immunol. 9:880-886(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Structure of an integrin with an alphaI domain, complement receptor type 4."
EMBO J. 29:666-679(2010) [PubMed] [Europe PMC] [Abstract]

"Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency."
J. Clin. Invest. 85:977-981(1990) [PubMed] [Europe PMC] [Abstract]

"Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates."
J. Exp. Med. 172:335-345(1990) [PubMed] [Europe PMC] [Abstract]

"Leukocyte adhesion deficiency: identification of novel mutations in two Japanese patients with a severe form."
Biochem. Biophys. Res. Commun. 184:1460-1467(1992) [PubMed] [Europe PMC] [Abstract]

"Molecular basis for a severe case of leukocyte adhesion deficiency."
Eur. J. Immunol. 22:1877-1881(1992) [PubMed] [Europe PMC] [Abstract]

"Identification of two molecular defects in a child with leukocyte adherence deficiency."
J. Biol. Chem. 267:5482-5487(1992) [PubMed] [Europe PMC] [Abstract]

"A point mutation associated with leukocyte adhesion deficiency type 1 of moderate severity."
Biochem. Biophys. Res. Commun. 193:912-918(1993) [PubMed] [Europe PMC] [Abstract]

"A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1."
J. Clin. Invest. 103:97-106(1999) [PubMed] [Europe PMC] [Abstract]

"A novel point mutation in CD18 causing leukocyte adhesion deficiency in a Chinese patient."
Chin. Med. J. 123:1278-1282(2010) [PubMed] [Europe PMC] [Abstract]

"Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene."
J. Clin. Immunol. 30:756-760(2010) [PubMed] [Europe PMC] [Abstract]