C-Type Lectin Domain Family 4, Member L (CLEC4L)
CD209; DC-SIGN; CDSIGN; Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-Integrin
DC-SIGN is a C-type lectin receptor present on both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4 T cells, as well as recognition of pathogen haptens.DC-SIGN is a C-type lectin and has a high affinity for the ICAM3 molecule. It binds various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes and especially functions as receptor for several viruses such as HIV and Hepatitis C.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Hu01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Hu01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Hu01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Hu01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Hu01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Mu01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Mu01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Mu01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Mu01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Mu01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Ra01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Ra01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Ra01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Ra01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Ra01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Ca01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Ca01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Ca01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Ca01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Ca01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Po01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Po01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Po01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Po01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Po01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Bo01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Bo01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Bo01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Bo01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Bo01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Rb01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Rb01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Rb01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Rb01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Rb01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV221Mo01 | Recombinant C-Type Lectin Domain Family 4, Member L (CLEC4L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV221Mo01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IP. |
| PAV221Mo01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member L (CLEC4L) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV221Mo01 | CLIA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | CLIA assay for Antigen Detection |
| ELV221Mo01 | ELISA Kit for C-Type Lectin Domain Family 4, Member L (CLEC4L) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp 120."
Proc. Natl. Acad. Sci. U.S.A. 89:8356-8360(1992) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13."
J. Immunol. 165:2937-2942(2000) [PubMed] [Europe PMC] [Abstract]
"A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection."
J. Exp. Med. 193:671-678(2001) [PubMed] [Europe PMC] [Abstract]
"Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts."
J. Biol. Chem. 276:33196-33212(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells."
Cell 100:587-597(2000) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking."
Nat. Immunol. 1:353-357(2000) [PubMed] [Europe PMC] [Abstract]
"A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands."
J. Biol. Chem. 276:28939-28945(2001) [PubMed] [Europe PMC] [Abstract]
"Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection."
Immunity 17:653-664(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1."
J. Biol. Chem. 277:11314-11320(2002) [PubMed] [Europe PMC] [Abstract]
"The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells."
J. Immunol. 168:2118-2126(2002) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection."
Immunity 16:135-144(2002) [PubMed] [Europe PMC] [Abstract]
"Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR."
J. Virol. 77:1337-1346(2003) [PubMed] [Europe PMC] [Abstract]
"Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN."
J. Virol. 77:5313-5323(2003) [PubMed] [Europe PMC] [Abstract]
"Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells."
J. Immunol. 170:1635-1639(2003) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN: escape mechanism for pathogens."
Nat. Rev. Immunol. 3:697-709(2003) [PubMed] [Europe PMC] [Abstract]
"The role of dendritic cell C-type lectin receptors in HIV pathogenesis."
J. Leukoc. Biol. 74:710-718(2003) [PubMed] [Europe PMC] [Abstract]
"L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus."
Proc. Natl. Acad. Sci. U.S.A. 101:14067-14072(2004) [PubMed] [Europe PMC] [Abstract]
"A variant in the CD209 promoter is associated with severity of dengue disease."
Nat. Genet. 37:507-513(2005) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells."
Blood 120:1228-1236(2012) [PubMed] [Europe PMC] [Abstract]
"Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR."
Science 294:2163-2166(2001) [PubMed] [Europe PMC] [Abstract]
"Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis."
PLoS Med. 3:230-235(2006) [PubMed] [Europe PMC] [Abstract]