Surfactant Associated Protein B (SPB)
SFTPB; PSPB; SFTB3; SFTP3; SP-B; Pulmonary Surfactant Protein B; 18 kDa pulmonary-surfactant protein; 6 kDa protein
SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure.
The SFTPB is an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Hu01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Hu01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Hu01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Hu01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Hu01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Mu01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Mu01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Mu01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Mu01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Mu01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Ra01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Ra01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Ra01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Ra01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Ra01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Ca01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Ca01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Ca01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Ca01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Ca01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Po01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Po01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Po01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Po01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Po01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Bo01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Bo01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Bo01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Bo01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Bo01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Rb01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Rb01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Rb01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Rb01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Rb01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV214Mo01 | Recombinant Surfactant Associated Protein B (SPB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV214Mo01 | Monoclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IP. |
| PAV214Mo01 | Polyclonal Antibody to Surfactant Associated Protein B (SPB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV214Mo01 | CLIA Kit for Surfactant Associated Protein B (SPB) | CLIA assay for Antigen Detection |
| ELV214Mo01 | ELISA Kit for Surfactant Associated Protein B (SPB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein."
J. Biol. Chem. 262:9808-9811(1987) [PubMed] [Europe PMC] [Abstract]
"Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B."
DNA 8:75-86(1989) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe)."
Proc. Natl. Acad. Sci. U.S.A. 84:4007-4011(1987) [PubMed] [Europe PMC] [Abstract]
"Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity."
J. Clin. Invest. 81:826-833(1988) [PubMed] [Europe PMC] [Abstract]
"Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form."
FEBS Lett. 301:165-167(1992) [PubMed] [Europe PMC] [Abstract]
"Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy."
J. Pept. Res. 55:330-347(2000) [PubMed] [Europe PMC] [Abstract]
"Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles."
Biochemistry 46:11047-11056(2007) [PubMed] [Europe PMC] [Abstract]
"Partial deficiency of surfactant protein B in an infant with chronic lung disease."
Pediatrics 96:1046-1052(1995) [PubMed] [Europe PMC] [Abstract]
"Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS."
Clin. Genet. 58:181-191(2000) [PubMed] [Europe PMC] [Abstract]
"Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome."
Hum. Mol. Genet. 9:2751-2760(2000) [PubMed] [Europe PMC] [Abstract]