Glucose Transporter 3 (GLUT3)

SLC2A3; Solute Carrier Family 2(Facilitated Glucose Transporter)Member 3; Glucose transporter type 3, brain

SPN	V202
HGNC	11007
MGI	95757
PubMed	21321936
RGD	3706
UniProt	P11169
Wiki	GLUT3

GLUT3 is a high-affinity isoform of Type I glucose transporter expressed mostly in neurons where it is believed to be the main glucose transporter isoform, and in the placenta. GLUTs are integral membrane proteins which contain 12 membrane spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. GLUT proteins transport glucose and related hexoses according to a model of alternate conformation, which predicts that the transporter exposes a single substrate binding site toward either the outside or the inside of the cell. Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane.

Reference

"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues."
J. Biol. Chem. 263:15245-15248(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site."
Biochemistry 37:1322-1326(1998) [PubMed] [Europe PMC] [Abstract]