Malonyl Coenzyme A Decarboxylase (MLYCD)
MCD; Malonyl-CoA decarboxylase, mitochondrial
Malonyl-CoA decarboxylase (EC 4.1.1.9) catalyzes the conversion of malonyl-CoA to acetyl-CoA and carbon dioxide. It is thought to be involved in aspects of fatty acid biosynthesis and oxidation.
Malonyl-CoA decarboxylase is found most often in the liver, brain, heart, and skeletal muscle. Gao et al. (1999) searched expressed sequence tag databases to identify human cDNAs with homology to the goose malonyl-CoA decarboxylase cDNA sequence. The 1,479-nucleotide human cDNA sequence is 70% identical to that of goose. FitzPatrick et al. (1999) identified a 2.1-kb human MCD cDNA encoding a 454-amino acid protein that shows 70.3% amino acid identity to goose Mcd.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Hu01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Hu01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Hu01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Hu01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Hu01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Mu01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Mu01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Mu01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Mu01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Mu01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Ra01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Ra01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Ra01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Ra01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Ra01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Ca01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Ca01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Ca01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Ca01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Ca01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Po01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Po01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Po01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Po01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Po01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Bo01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Bo01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Bo01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Bo01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Bo01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Rb01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Rb01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Rb01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Rb01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Rb01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV174Mo01 | Recombinant Malonyl Coenzyme A Decarboxylase (MLYCD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV174Mo01 | Monoclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IP. |
| PAV174Mo01 | Polyclonal Antibody to Malonyl Coenzyme A Decarboxylase (MLYCD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV174Mo01 | CLIA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | CLIA assay for Antigen Detection |
| ELV174Mo01 | ELISA Kit for Malonyl Coenzyme A Decarboxylase (MLYCD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The molecular basis of malonyl-CoA decarboxylase deficiency."
Am. J. Hum. Genet. 65:318-326(1999) [PubMed] [Europe PMC] [Abstract]
"MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency."
J. Biol. Chem. 274:24461-24468(1999) [PubMed] [Europe PMC] [Abstract]
"Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase."
J. Lipid Res. 40:178-182(1999) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression, purification, and characterization of human malonyl-CoA decarboxylase."
Protein Expr. Purif. 34:261-269(2004) [PubMed] [Europe PMC] [Abstract]
"Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle."
Diabetes 57:1508-1516(2008) [PubMed] [Europe PMC] [Abstract]
"A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities."
J. Am. Chem. Soc. 132:3973-3979(2010) [PubMed] [Europe PMC] [Abstract]
"Structural asymmetry and disulphide bridges among subunits modulate the activity of human Malonyl-CoA Decarboxylase."
J. Biol. Chem. 288:11907-11919(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations."
Structure 21:1182-1192(2013) [PubMed] [Europe PMC] [Abstract]