Titin (TTN)
CMD1G; CMH9; CMPD4; HMERF; LGMD2J; TMD; Cardiomyopathy,Dilated 1G(Autosomal Dominant)
Titin is a large abundant protein of striated muscle. A N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere respectively so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Of the many titin variants identified, five for which complete transcript information is available are described.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Hu01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Hu01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Hu01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Hu01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Hu01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Mu01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Mu01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Mu01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Mu01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Mu01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Ra01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Ra01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Ra01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Ra01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Ra01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Ca01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Ca01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Ca01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Ca01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Ca01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Po01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Po01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Po01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Po01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Po01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Bo01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Bo01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Bo01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Bo01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Bo01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Rb01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Rb01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Rb01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Rb01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Rb01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV171Mo01 | Recombinant Titin (TTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV171Mo01 | Monoclonal Antibody to Titin (TTN) | WB; IHC; ICC; IP. |
| PAV171Mo01 | Polyclonal Antibody to Titin (TTN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV171Mo01 | CLIA Kit for Titin (TTN) | CLIA assay for Antigen Detection |
| ELV171Mo01 | ELISA Kit for Titin (TTN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Titins, giant proteins in charge of muscle ultrastructure and elasticity."
Science 270:293-296(1995) [PubMed] [Europe PMC] [Abstract]
"Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity."
Circ. Res. 86:1114-1121(2000) [PubMed] [Europe PMC] [Abstract]
"The complete gene sequence of titin, expression of an unusual ~700 kDa titin isoform and its interaction with obscurin identify a novel Z-line to I-band linking system."
Circ. Res. 89:1065-1072(2001) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers."
J. Cell Sci. 109:2747-2754(1996) [PubMed] [Europe PMC] [Abstract]
"Dissecting titin into its structural motifs: identification of an alpha helix near the N-terminus."
Biochemistry 34:553-561(1995) [PubMed] [Europe PMC] [Abstract]
"Familial dilated cardiomyopathy locus maps to chromosome 2q31."
Circulation 99:1022-1026(1999) [PubMed] [Europe PMC] [Abstract]
"Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension."
J. Muscle Res. Cell Motil. 23:473-482(2002) [PubMed] [Europe PMC] [Abstract]