Melanoma Cell Adhesion Molecule (MCAM)
CD146; MUC18; Cell surface glycoprotein P1H12; Melanoma-associated antigen A32; S-endo 1 endothelial-associated antigen
CD146 (cluster of differentiation 146) is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.
Its function is still poorly understood, but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton. A member of the Immunoglobulin superfamily, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Hu01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Hu01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Hu01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Hu01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Hu01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Mu01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Mu01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Mu01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Mu01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Mu01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Ra01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Ra01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Ra01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Ra01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Ra01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Ca01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Ca01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Ca01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Ca01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Ca01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Po01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Po01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Po01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Po01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Po01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Bo01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Bo01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Bo01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Bo01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Bo01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Rb01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Rb01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Rb01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Rb01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Rb01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV168Mo01 | Recombinant Melanoma Cell Adhesion Molecule (MCAM) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV168Mo01 | Monoclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IP. |
PAV168Mo01 | Polyclonal Antibody to Melanoma Cell Adhesion Molecule (MCAM) | WB; IHC; ICC; IF. | |
Assay Kits | CLV168Mo01 | CLIA Kit for Melanoma Cell Adhesion Molecule (MCAM) | CLIA assay for Antigen Detection |
ELV168Mo01 | ELISA Kit for Melanoma Cell Adhesion Molecule (MCAM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily."
Proc. Natl. Acad. Sci. U.S.A. 86:9891-9895(1989) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains."
Proc. Natl. Acad. Sci. U.S.A. 90:8514-8518(1993) [PubMed] [Europe PMC] [Abstract]
"Identification and functional assessment of endothelial P1H12."
J. Lab. Clin. Med. 138:322-331(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation and functional characterization of the A32 melanoma-associated antigen."
Cancer Res. 54:2514-2520(1994) [PubMed] [Europe PMC] [Abstract]
"Identification of the S-endo 1 endothelial-associated antigen."
Biochem. Biophys. Res. Commun. 218:210-216(1996) [PubMed] [Europe PMC] [Abstract]
"The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family."
Melanoma Res. 3:337-340(1993) [PubMed] [Europe PMC] [Abstract]
"Outside-in signaling pathway linked to CD146 engagement in human endothelial cells."
J. Biol. Chem. 276:1564-1569(2001) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]