Melanotransferrin (MFI2)
CD228; MAP97; MTF1; Antigen P97(Melanoma Associated); Membrane-Bound Transferrin-Like Protein
Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. P97 is a 97,000 molecular weight cell-surface glycoprotein found in human melanomas. Amino acid sequence and iron-binding properties are similar to those of transferrin, lactotransferrin and ovotransferrin; together these constitute a superfamily.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Hu01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Hu01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Hu01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Hu01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Hu01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Mu01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Mu01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Mu01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Mu01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Mu01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Ra01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Ra01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Ra01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Ra01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Ra01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Ca01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Ca01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Ca01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Ca01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Ca01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Po01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Po01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Po01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Po01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Po01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Bo01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Bo01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Bo01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Bo01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Bo01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Rb01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Rb01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Rb01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Rb01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Rb01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV162Mo01 | Recombinant Melanotransferrin (MFI2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV162Mo01 | Monoclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IP. |
| PAV162Mo01 | Polyclonal Antibody to Melanotransferrin (MFI2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV162Mo01 | CLIA Kit for Melanotransferrin (MFI2) | CLIA assay for Antigen Detection |
| ELV162Mo01 | ELISA Kit for Melanotransferrin (MFI2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence."
Proc. Natl. Acad. Sci. U.S.A. 83:1261-1265(1986) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97."
J. Exp. Med. 169:585-590(1989) [PubMed] [Europe PMC] [Abstract]
"Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein."
J. Biol. Chem. 269:3034-3040(1994) [PubMed] [Europe PMC] [Abstract]
"A novel iron uptake mechanism mediated by GPI-anchored human p97."
EMBO J. 14:4178-4186(1995) [PubMed] [Europe PMC] [Abstract]
"Human melanotransferrin (p97) has only one functional iron-binding site."
FEBS Lett. 298:215-218(1992) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function."
FEBS Lett. 305:55-61(1992) [PubMed] [Europe PMC] [Abstract]