B-Cell Activating Factor (BAFF)
CD257; TNFSF13B; BLYS; TALL1; THANK; TNFSF20; ZTNF4; B lymphocyte stimulator; Tumor Necrosis Factor Ligand Superfamily Member 13B; Dendritic cell-derived TNF-like
B-cell activating factor (BAFF) is the tumor necrosis factor ligand superfamily member 13B (TNFLSF13B), also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived TNF-like molecule (CD257 antigen; cluster of differentiation 257). BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124. It is expressed as transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. The transmembrane form can be cleaved from the membrane, generating a soluble protein fragment. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R, TACI, and BCMA, all of which have differing binding affinities for it.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Hu01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Hu01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Hu01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Hu01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Hu01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Mu01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Mu01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Mu01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Mu01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Mu01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Ra01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Ra01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Ra01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Ra01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Ra01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Ca01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Ca01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Ca01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Ca01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Ca01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Po01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Po01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Po01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Po01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Po01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Bo01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Bo01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Bo01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Bo01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Bo01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Rb01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Rb01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Rb01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Rb01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Rb01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV153Mo01 | Recombinant B-Cell Activating Factor (BAFF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV153Mo01 | Monoclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IP. |
| PAV153Mo01 | Polyclonal Antibody to B-Cell Activating Factor (BAFF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV153Mo01 | CLIA Kit for B-Cell Activating Factor (BAFF) | CLIA assay for Antigen Detection |
| ELV153Mo01 | ELISA Kit for B-Cell Activating Factor (BAFF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"TALL-1 is a novel member of the TNF family that is down-regulated by mitogens."
J. Leukoc. Biol. 65:680-683(1999) [PubMed] [Europe PMC] [Abstract]
"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth."
J. Exp. Med. 189:1747-1756(1999) [PubMed] [Europe PMC] [Abstract]
"BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator."
Science 285:260-263(1999) [PubMed] [Europe PMC] [Abstract]
"DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF."
J. Biol. Chem. 278:38220-38228(2003) [PubMed] [Europe PMC] [Abstract]
"The complexity of the BAFF TNF-family members: implications for autoimmunity."
J. Autoimmun. 39:189-198(2012) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Nat. Immunol. 1:252-256(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands."
Cell 108:383-394(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes."
J. Mol. Biol. 315:1145-1154(2002) [PubMed] [Europe PMC] [Abstract]
"Structural basis of BLyS receptor recognition."
Nat. Struct. Biol. 9:288-292(2002) [PubMed] [Europe PMC] [Abstract]