Interleukin 28A (IL28A)
IFNL2; Interferon,Lambda 2; Cytokine Zcyto20
Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29.
Interleukin-28A (IL-28A) is a novel cytokine discovered in recent years and has been shown to have antiviral activity. IL-28A, IL-28B and IL-29 are a family of class II cytokines that stimulate antiviral responses through a heterodimeric receptor that is distinct from the type I interferon (IFN) receptor.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Hu01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Hu01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Hu01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Hu01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Hu01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Mu01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Mu01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Mu01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Mu01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Mu01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Ra01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Ra01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Ra01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Ra01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Ra01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Ca01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Ca01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Ca01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Ca01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Ca01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Po01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Po01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Po01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Po01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Po01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Bo01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Bo01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Bo01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Bo01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Bo01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Rb01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Rb01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Rb01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Rb01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Rb01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV150Mo01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV150Mo01 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAV150Mo01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV150Mo01 | CLIA Kit for Interleukin 28A (IL28A) | CLIA assay for Antigen Detection |
| ELV150Mo01 | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"IL-28, IL-29 and their class II cytokine receptor IL-28R."
Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
"Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication."
Virol. J. 2:80-80(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
"Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."
Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
"Interferon-lambda: a new addition to an old family."
J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
"Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]