Myogenic Differentiation (MyoD)
MYOD1; PUM; MYF3; bHLHc1; Myoblast Determination Protein 1; Myogenic Factor 3; Class C basic helix-loop-helix protein 1
MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 (Myf6).
MYOD is directly acetylated by PCAF at evolutionarily conserved lysines. Acetylated MYOD displayed an increased affinity for its DNA target. Conservative substitutions of acetylated lysines with nonacetylatable arginines impaired the ability of MYOD to stimulate transcription and to induce conversion, indicating that acetylation of MYOD is functionally critical. MYOD mRNA was also downregulated by TNF and IFNG expression in mouse muscle in vivo.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Hu01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Hu01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Hu01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Hu01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Hu01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Mu01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Mu01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Mu01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Mu01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Mu01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Ra01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Ra01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Ra01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Ra01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Ra01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Ca01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Ca01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Ca01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Ca01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Ca01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Po01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Po01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Po01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Po01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Po01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Bo01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Bo01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Bo01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Bo01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Bo01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Rb01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Rb01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Rb01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Rb01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Rb01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV147Mo01 | Recombinant Myogenic Differentiation (MyoD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV147Mo01 | Monoclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IP. |
| PAV147Mo01 | Polyclonal Antibody to Myogenic Differentiation (MyoD) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV147Mo01 | CLIA Kit for Myogenic Differentiation (MyoD) | CLIA assay for Antigen Detection |
| ELV147Mo01 | ELISA Kit for Myogenic Differentiation (MyoD) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human MyoD: cDNA and deduced amino acid sequence."
Nucleic Acids Res. 19:1148-1148(1991) [PubMed] [Europe PMC] [Abstract]
"Methylation alterations of the MyoD1 upstream region are predictive of subclassification of human rhabdomyosarcomas."
Am. J. Pathol. 152:1071-1079(1998) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products."
EMBO J. 8:3617-3625(1989) [PubMed] [Europe PMC] [Abstract]
"A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein."
EMBO J. 17:5964-5973(1998) [PubMed] [Europe PMC] [Abstract]
"Control of muscle development by dueling HATs and HDACs."
Curr. Opin. Genet. Dev. 11:497-504(2001) [PubMed] [Europe PMC] [Abstract]
"Activation of MyoD-dependent transcription by cdk9/cyclin T2."
Oncogene 21:4137-4148(2002) [PubMed] [Europe PMC] [Abstract]
"Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation."
EMBO J. 25:3323-3334(2006) [PubMed] [Europe PMC] [Abstract]
"Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation."
Proc. Natl. Acad. Sci. U.S.A. 109:841-846(2012) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]