Defensin Alpha 1, Neutrophil (DEFa1)

DEF1; DEFA2; HNP-1; HP-1; MRS; DEF3; HNP-3; HNP3; HP-3; Defensin,Alpha 1; Myeloid-Related Sequence

SPN	V134
HGNC	2761
MGI	94880
PubMed	22219625
UniProt	P59665
Wiki	DEFA1

• Defensins are cytotoxic peptides and have a well-defined role in host defense. Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8.

• The defensin, alpha 1 protein, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 3 by only one amino acid.

Reference

"Isolation and characterization of human defensin cDNA clones."
Proc. Natl. Acad. Sci. U.S.A. 85:7327-7331(1988) [PubMed] [Europe PMC] [Abstract]

"A myeloid-related sequence that localizes to human chromosome 8q21.1-22."
Blood 71:1713-1719(1988) [PubMed] [Europe PMC] [Abstract]

"Differentiation stage-specific expression of a gene during granulopoiesis."
Leukemia 3:227-234(1989) [PubMed] [Europe PMC] [Abstract]

"Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3."
J. Biol. Chem. 270:30371-30376(1995) [PubMed] [Europe PMC] [Abstract]

"The structure of neutrophil defensin genes."
FEBS Lett. 321:267-273(1993) [PubMed] [Europe PMC] [Abstract]

Erratum
FEBS Lett. 326:299-300(1993) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Primary structures of three human neutrophil defensins."
J. Clin. Invest. 76:1436-1439(1985) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide."
J. Biol. Chem. 264:4003-4007(1989) [PubMed] [Europe PMC] [Abstract]

"The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells."
J. Biol. Chem. 266:7524-7530(1991) [PubMed] [Europe PMC] [Abstract]

"Posttranslational processing of defensins in immature human myeloid cells."
Blood 79:1538-1544(1992) [PubMed] [Europe PMC] [Abstract]

"Antibacterial activity and specificity of the six human alpha-defensins."
Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]

"Structural and functional consequences induced by post-translational modifications in alpha-Defensins."
Int. J. Pept. 2011:594723-594723(2011) [PubMed] [Europe PMC] [Abstract]

"NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1."
Biochemistry 31:11348-11356(1992) [PubMed] [Europe PMC] [Abstract]

"NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1."
Biochemistry 31:11357-11364(1992) [PubMed] [Europe PMC] [Abstract]

"Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs."
J. Biol. Chem. 282:19653-19665(2007) [PubMed] [Europe PMC] [Abstract]