Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1)
SQS; SS; Squalene Synthase; FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase (FDFT1) is an enzyme that converts two units of farnesyl pyrophosphate into squalene.It has been described as the first dedicated enzyme of sterol (i.e., cholesterol, etc.) synthesis, since the squalene formed by it is exclusively routed into various sterols via a complex, multi-step pathway.Squalene synthase is considered to be an enzyme of eukaryotes or advanced organisms, although at least one prokaryote has been shown to possess a functionally similar enzyme.
In terms of structure and mechanics, squalene synthase most closely resembles phytoene syntase, which serves a similar role in many plants in the elaboration of phytoene, a precursor of many carotenoid compounds.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Hu01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Hu01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Hu01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Hu01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Hu01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Mu01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Mu01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Mu01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Mu01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Mu01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Ra01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Ra01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Ra01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Ra01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Ra01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Ca01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Ca01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Ca01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Ca01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Ca01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Po01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Po01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Po01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Po01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Po01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Bo01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Bo01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Bo01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Bo01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Bo01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Rb01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Rb01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Rb01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Rb01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Rb01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV131Mo01 | Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV131Mo01 | Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IP. |
| PAV131Mo01 | Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV131Mo01 | CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | CLIA assay for Antigen Detection |
| ELV131Mo01 | ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation."
Mol. Cell. Biol. 13:2706-2717(1993) [PubMed] [Europe PMC] [Abstract]
"Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase."
J. Biol. Chem. 268:12818-12824(1993) [PubMed] [Europe PMC] [Abstract]
"Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase."
Gene 136:185-192(1993) [PubMed] [Europe PMC] [Abstract]
"Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems."
Arch. Biochem. Biophys. 316:713-723(1995) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis."
J. Biol. Chem. 275:30610-30617(2000) [PubMed] [Europe PMC] [Abstract]
"K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population."
Hum. Mutat. 29:689-694(2008) [PubMed] [Europe PMC] [Abstract]