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Glycophorin C (GYPC)

CD236; CD236R; GYP-C; PAS-2; GPC; GYPD; Ge; Glycoprotein Beta; Glycoconnectin; Gerbich Blood Group; Glycophorin-D; Sialoglycoprotein D

Glycophorin C (GPC) is a single polypeptide chain of 128 amino acids and is encoded by a gene on the long arm of Chromosome 2 (2q14-q21). Two isoforms are known and the gene is expressed in a wide variety of tissues including kidney, thymus, stomach, breast, adult liver and erythrocyte. In the non erythroid cell lines, expression is lower than in the erythrocyte and the protein is differentially glycosylated. In the erythrocyte glycophorin C makes up ~4% of the membrane sialoglycoproteins.
The GPC gene is organized in four exons distributed over 13.5 kilobase pairs of DNA and contains two directly repeated domains 3.4 kilobase pairs long which may be derived from a recent duplication of a single ancestral domain.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Hu01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Hu01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Hu01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Hu01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Hu01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Mu01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Mu01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Mu01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Mu01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Mu01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Ra01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Ra01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Ra01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Ra01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Ra01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Ca01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Ca01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Ca01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Ca01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Ca01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Po01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Po01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Po01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Po01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Po01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Bo01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Bo01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Bo01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Bo01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Bo01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Rb01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Rb01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Rb01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Rb01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Rb01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV128Mo01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV128Mo01 Monoclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
PAV128Mo01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IF.
Assay Kits CLV128Mo01 CLIA Kit for Glycophorin C (GYPC) CLIA assay for Antigen Detection
ELV128Mo01 ELISA Kit for Glycophorin C (GYPC) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C."
J. Biol. Chem. 261:229-233(1986) [PubMed] [Europe PMC] [Abstract]

"Human erythrocyte membrane sialoglycoprotein beta. The cDNA sequence suggests the absence of a cleaved N-terminal signal sequence."
Biochem. J. 243:277-280(1987) [PubMed] [Europe PMC] [Abstract]

"Structure of human erythrocyte glycophorin C deduced from cDNA analysis."
Rev. Fr. Transfus. Immunohematol. 29:267-285(1986) [PubMed] [Europe PMC] [Abstract]

"Gerbich blood group deficiency of the Ge:-1,-2,-3 and Ge:-1,-2,3 types. Immunochemical study and genomic analysis with cDNA probes."
Eur. J. Biochem. 165:571-579(1987) [PubMed] [Europe PMC] [Abstract]

"An ubiquitous isoform of glycophorin C is produced by alternative splicing."
Nucleic Acids Res. 18:3076-3076(1990) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis."
J. Biol. Chem. 262:5808-5811(1987) [PubMed] [Europe PMC] [Abstract]

"Isolation and structural analysis of glycophorin C."
Biol. Chem. Hoppe-Seyler 366:777-778(1985)

"A revision of the N-terminal structure of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes."
Biol. Chem. Hoppe-Seyler 366:1067-1070(1985) [PubMed] [Europe PMC] [Abstract]

"N-terminal amino acid sequence of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes."
Eur. J. Biochem. 125:57-62(1982) [PubMed] [Europe PMC] [Abstract]

"Structural homology between glycophorins C and D of human erythrocytes."
Eur. J. Biochem. 183:639-643(1989) [PubMed] [Europe PMC] [Abstract]

"Structure of the promoter region and tissue specificity of the human glycophorin C gene."
J. Biol. Chem. 264:20407-20414(1989) [PubMed] [Europe PMC] [Abstract]

"Rearrangements of the red-cell membrane glycophorin C (sialoglycoprotein beta) gene. A further study of alterations in the glycophorin C gene."
Biochem. J. 262:47-54(1989) [PubMed] [Europe PMC] [Abstract]

"Human erythrocyte glycophorin C. Gene structure and rearrangement in genetic variants."
J. Biol. Chem. 264:3773-3780(1989) [PubMed] [Europe PMC] [Abstract]

"Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations."
Nat. Med. 9:87-92(2003) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of erythrocyte glycophorin C variants."
Blood 77:644-648(1991) [PubMed] [Europe PMC] [Abstract]

"Point mutation in the glycophorin C gene results in the expression of the blood group antigen Dha."
Vox Sang. 63:56-58(1992) [PubMed] [Europe PMC] [Abstract]

"A point mutation in the GYPC gene results in the expression of the blood group Ana antigen on glycophorin D but not on glycophorin C: further evidence that glycophorin D is a product of the GYPC gene."
Blood 82:3198-3203(1993) [PubMed] [Europe PMC] [Abstract]