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Growth Differentiation Factor 2 (GDF2)

BMP9; Bone Morphogenetic Protein 9

Growth differentiation factor 2 (GDF2) is a protein also known as bone morphogenetic protein (BMP)-9 that belongs to the transforming growth factor beta superfamily. It has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention. GDF2 is also important for the maturation of BFCN.

Another role of GDF2 has been recently suggested. GDF2 is a potent inducer of hepcidin  in liver cells (hepatocytes) and can regulate iron metabolism. The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Hu01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Hu01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Hu01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Hu01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Hu01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Mu01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Mu01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Mu01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Mu01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Mu01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Ra01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Ra01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Ra01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Ra01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Ra01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Ca01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Ca01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Ca01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Ca01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Ca01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Po01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Po01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Po01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Po01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Po01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Bo01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Bo01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Bo01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Bo01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Bo01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Rb01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Rb01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Rb01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Rb01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Rb01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV111Mo01 Recombinant Growth Differentiation Factor 2 (GDF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV111Mo01 Monoclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IP.
PAV111Mo01 Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2) WB; IHC; ICC; IF.
Assay Kits CLV111Mo01 CLIA Kit for Growth Differentiation Factor 2 (GDF2) CLIA assay for Antigen Detection
ELV111Mo01 ELISA Kit for Growth Differentiation Factor 2 (GDF2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."
J. Biol. Chem. 287:27313-27325(2012) [PubMed] [Europe PMC] [Abstract]

"BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia."
Am. J. Hum. Genet. 93:530-537(2013) [PubMed] [Europe PMC] [Abstract]