C-Type Lectin Domain Family 4, Member M (CLEC4M)
CD299; CD209L; DC-SIGN2; DC-SIGNR; L-SIGN; CD209 like 1; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; Liver/lymph node-specific ICAM-3-grabbing non-integrin
C-type lectin domain family 4 member M is a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes.
The CD209L protein has an N-terminal cytoplasmic tail with a dileucine motif, which is an internalization sequence; a 22-residue transmembrane domain; an N-linked glycosylation site; a neck containing 7 repeats of a 23-residue sequence; and carbohydrate recognition domains (CRDs), which are required for calcium-dependent mannose binding.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Hu01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Hu01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Hu01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Hu01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Hu01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Mu01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Mu01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Mu01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Mu01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Mu01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Ra01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Ra01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Ra01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Ra01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Ra01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Ca01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Ca01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Ca01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Ca01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Ca01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Po01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Po01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Po01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Po01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Po01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Bo01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Bo01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Bo01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Bo01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Bo01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Rb01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Rb01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Rb01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Rb01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Rb01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV109Mo01 | Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV109Mo01 | Monoclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IP. |
| PAV109Mo01 | Polyclonal Antibody to C-Type Lectin Domain Family 4, Member M (CLEC4M) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV109Mo01 | CLIA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | CLIA assay for Antigen Detection |
| ELV109Mo01 | ELISA Kit for C-Type Lectin Domain Family 4, Member M (CLEC4M) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Gene 228:161-167(1999) [PubMed] [Europe PMC] [Abstract]
"DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13."
J. Immunol. 165:2937-2942(2000) [PubMed] [Europe PMC] [Abstract]
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J. Virol. 77:1337-1346(2003) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 101:14067-14072(2004) [PubMed] [Europe PMC] [Abstract]
"CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus."
Proc. Natl. Acad. Sci. U.S.A. 101:15748-15753(2004) [PubMed] [Europe PMC] [Abstract]
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Science 294:2163-2166(2001) [PubMed] [Europe PMC] [Abstract]
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"The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer."
J. Mol. Biol. 347:979-989(2005) [PubMed] [Europe PMC] [Abstract]