Signal Transducer And Activator Of Transcription 5A (STAT5A)

MGF; STAT5-A

SPN	V101
HGNC	11366
MGI	103036
PubMed	12407017
RGD	3773
UniProt	P42229
Wiki	STAT5A

STAT5A  is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Reference

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Immunity 2:321-329(1995) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus."
Mol. Endocrinol. 16:58-69(2002) [PubMed] [Europe PMC] [Abstract]

"NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain."
J. Biol. Chem. 278:45340-45351(2003) [PubMed] [Europe PMC] [Abstract]

"STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA."
Mol. Biol. Cell 14:40-53(2003) [PubMed] [Europe PMC] [Abstract]

"FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy."
Blood 103:1085-1088(2004) [PubMed] [Europe PMC] [Abstract]

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Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

"The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone."
J. Cell Biol. 167:469-478(2004) [PubMed] [Europe PMC] [Abstract]

"Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation."
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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
J. Biol. Chem. 286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]