Transglutaminase 1, Keratinocyte (TGM1)
TGK; ICR2; KTG; LI; LI1; TGASE; Transglutaminase K; K Polypeptide Epidermal Type I; Protein-Glutamine-Gamma-Glutamyltransferase
The TGM1 gene encodes transglutaminase-1, a catalytic membrane-bound enzyme that functions in the formation of the epidermal cornified cell envelope, which acts as a mechanical barrier to protect against water loss and infectious agents (Farasat et al., 2009).
Kim et al. (1992) demonstrated 2 variant forms of the TGM1 gene, the rarer of which contains a 2-nucleotide deletion near the 5-prime end, uses an alternate initiation codon, and differs from the common larger variant only in the first 15 amino acids. Furthermore, they showed that the DNA sequences of intron 14 possess several tracts of dinucleotide repeats that show wide size polymorphism in the human population.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Hu01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Hu01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Hu01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Hu01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Hu01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Mu01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Mu01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Mu01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Mu01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Mu01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Ra01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Ra01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Ra01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Ra01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Ra01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Ca01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Ca01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Ca01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Ca01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Ca01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Po01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Po01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Po01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Po01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Po01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Bo01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Bo01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Bo01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Bo01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Bo01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Rb01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Rb01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Rb01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Rb01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Rb01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV067Mo01 | Recombinant Transglutaminase 1, Keratinocyte (TGM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV067Mo01 | Monoclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IP. |
| PAV067Mo01 | Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV067Mo01 | CLIA Kit for Transglutaminase 1, Keratinocyte (TGM1) | CLIA assay for Antigen Detection |
| ELV067Mo01 | ELISA Kit for Transglutaminase 1, Keratinocyte (TGM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure of keratinocyte transglutaminase."
Proc. Natl. Acad. Sci. U.S.A. 87:9333-9337(1990) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture."
Biochem. Biophys. Res. Commun. 175:906-913(1991) [PubMed] [Europe PMC] [Abstract]
"The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones."
J. Biol. Chem. 266:536-539(1991) [PubMed] [Europe PMC] [Abstract]
"Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function."
J. Biol. Chem. 267:2282-2286(1992) [PubMed] [Europe PMC] [Abstract]
"Structure and organization of the human transglutaminase 1 gene."
J. Biol. Chem. 267:7710-7717(1992) [PubMed] [Europe PMC] [Abstract]
"Structure of the gene for human transglutaminase 1."
J. Biol. Chem. 267:17858-17863(1992) [PubMed] [Europe PMC] [Abstract]
"Organization and evolution of the human epidermal keratinocyte transglutaminase I gene."
Proc. Natl. Acad. Sci. U.S.A. 89:4476-4480(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation of cDNA for human epidermal type I transglutaminase."
J. Invest. Dermatol. 96:285-288(1991) [PubMed] [Europe PMC] [Abstract]
"Type I keratinocyte transglutaminase: expression in human skin and psoriasis."
J. Invest. Dermatol. 99:27-34(1992) [PubMed] [Europe PMC] [Abstract]
"Identification of phosphorylation sites in keratinocyte transglutaminase."
Biochem. J. 320:547-550(1996) [PubMed] [Europe PMC] [Abstract]
"Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1."
Hum. Mutat. 30:537-547(2009) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human transglutaminase 1 beta-barrel domain."
Submitted (JAN-2011) to the PDB data bank
"Mutations of keratinocyte transglutaminase in lamellar ichthyosis."
Science 267:525-528(1995) [PubMed] [Europe PMC] [Abstract]
"Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis."
Nat. Genet. 9:279-283(1995) [PubMed] [Europe PMC] [Abstract]
"Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population."
Am. J. Hum. Genet. 61:529-538(1997) [PubMed] [Europe PMC] [Abstract]
"Novel mutations of TGM1 in a child with congenital ichthyosiform erythroderma."
Br. J. Dermatol. 144:401-407(2001) [PubMed] [Europe PMC] [Abstract]
"Novel mutations of the transglutaminase 1 gene in lamellar ichthyosis."
J. Invest. Dermatol. 117:214-218(2001) [PubMed] [Europe PMC] [Abstract]
"Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients."
J. Invest. Dermatol. 130:438-443(2010) [PubMed] [Europe PMC] [Abstract]