Phospholipid Scramblase 1 (PLSCR1)
MMTRA1B; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase
Scramblases are members of the general family of transmembrane lipid transporters known as flippases. The inner-leaflet facing the inside of the cell contains negatively-charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an enzyme, present in the cell membrane, that can transport (scramble) the negatively-charged phospholipids from the inner-leaflet to the outer-leaflet, and vice versa.Wiedmer et al. (2000) determined that the PLSCR1 gene contains 9 exons and spans about 30 kb. The first exon is untranslated. By deletion analysis of PLSCR1 promoter-reporter constructs, they found that 97% of the promoter activity resides between -95 bp in the 5-prime flanking region to +60 bp of the first exon.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Hu01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Hu01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Hu01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Hu01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Hu01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Mu01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Mu01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Mu01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Mu01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Mu01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Ra01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Ra01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Ra01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Ra01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Ra01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Ca01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Ca01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Ca01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Ca01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Ca01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Po01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Po01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Po01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Po01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Po01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Bo01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Bo01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Bo01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Bo01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Bo01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Rb01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Rb01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Rb01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Rb01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Rb01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV059Mo01 | Recombinant Phospholipid Scramblase 1 (PLSCR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV059Mo01 | Monoclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IP. |
| PAV059Mo01 | Polyclonal Antibody to Phospholipid Scramblase 1 (PLSCR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV059Mo01 | CLIA Kit for Phospholipid Scramblase 1 (PLSCR1) | CLIA assay for Antigen Detection |
| ELV059Mo01 | ELISA Kit for Phospholipid Scramblase 1 (PLSCR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids."
J. Biol. Chem. 272:18240-18244(1997) [PubMed] [Europe PMC] [Abstract]
"Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene."
Biochem. Biophys. Res. Commun. 249:449-455(1998) [PubMed] [Europe PMC] [Abstract]
"Identification of three new members of the phospholipid scramblase gene family."
Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid."
J. Biol. Chem. 271:17205-17210(1996) [PubMed] [Europe PMC] [Abstract]
"Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta."
J. Biol. Chem. 275:23065-23073(2000) [PubMed] [Europe PMC] [Abstract]
"c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1."
J. Biol. Chem. 276:28984-28990(2001) [PubMed] [Europe PMC] [Abstract]
"Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids."
Biochemistry 37:6361-6366(1998) [PubMed] [Europe PMC] [Abstract]
"Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids."
Biochemistry 37:2356-2360(1998) [PubMed] [Europe PMC] [Abstract]
"Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane."
Biochemistry 42:1227-1233(2003) [PubMed] [Europe PMC] [Abstract]
"Phospholipid scramblase 1 potentiates the antiviral activity of interferon."
J. Virol. 78:8983-8993(2004) [PubMed] [Europe PMC] [Abstract]
"Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression."
J. Biol. Chem. 280:35062-35068(2005) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases."
J. Biol. Chem. 289:13206-13218(2014) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha."
J. Biol. Chem. 280:10599-10606(2005) [PubMed] [Europe PMC] [Abstract]