Interleukin 32 (IL32)
NK4; TAIF; TAIFb; TAIFd; Natural Killer Cell Transcript 4; Natural killer cells protein 4; Tumor necrosis factor alpha-inducing factor
Interleukin 32 (IL-32) is a cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete tumor necrosis factor-alpha (TNF-α) in addition to chemokines such as IL-8 and MIP-2/CXCL2.IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.
Northern blot analysis revealed expression of a 1.0-kb transcript in activated NK and T cells, but no expression was detected in B cells or fibroblasts. Southern blot and sequence analyses indicated variable expression of NK4 in different individuals, suggesting that the NK4 gene is polymorphic. SDS-PAGE analysis showed expression of a 27-kD protein, in agreement with the predicted size.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Hu01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Hu01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Hu01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Hu01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Hu01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Mu01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Mu01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Mu01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Mu01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Mu01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Ra01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Ra01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Ra01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Ra01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Ra01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Ca01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Ca01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Ca01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Ca01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Ca01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Po01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Po01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Po01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Po01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Po01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Bo01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Bo01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Bo01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Bo01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Bo01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Rb01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Rb01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Rb01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Rb01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Rb01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV038Mo01 | Recombinant Interleukin 32 (IL32) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV038Mo01 | Monoclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IP. |
| PAV038Mo01 | Polyclonal Antibody to Interleukin 32 (IL32) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV038Mo01 | CLIA Kit for Interleukin 32 (IL32) | CLIA assay for Antigen Detection |
| ELV038Mo01 | ELISA Kit for Interleukin 32 (IL32) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of a novel gene expressed in activated natural killer cells and T cells."
J. Immunol. 148:597-603(1992) [PubMed] [Europe PMC] [Abstract]
"Interleukin-32: a cytokine and inducer of TNFalpha."
Immunity 22:131-142(2005) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Transcriptome analysis of human gastric cancer."
Mamm. Genome 16:942-954(2005) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]