Natural Cytotoxicity Triggering Receptor 3 (NCR3)

CD337; 1C7; LY117; NKp30; Lymphocyte Antigen 117; Activating natural killer receptor p30; Natural killer cell p30-related protein

SPN	V036
HGNC	19077
MGI	2149332
PubMed	23884468
UniProt	O14931
Wiki	NCR3

Natural cytotoxicity receptors (NCRs), such as NCR3, are activating natural killer (NK) cell receptors that belong to the immunoglobulin (Ig) superfamily. NCR3 is expressed in all resting and activated NK cells and forms a complex with CD3-zeta (CD3Z, or CD247)

The deduced 190-amino acid protein has a signal peptide followed by a 120-amino acid extracellular region that forms a V-type Ig-like domain with 2 potential N-linked glycosylation sites; a hydrophobic transmembrane region with a positively charged arg residue; and a 33-amino acid cytoplasmic tail lacking an immunoreceptor tyrosine-based activating motif (ITAM). Northern blot analysis detected a 1.0-kb transcript only in NK cells.

Reference

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Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor."
Blood 106:566-571(2005) [PubMed] [Europe PMC] [Abstract]

"Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells."
Immunity 27:965-974(2007) [PubMed] [Europe PMC] [Abstract]

"Association analyses of NCR3 polymorphisms with P. falciparum mild malaria."
Microbes Infect. 9:160-166(2007) [PubMed] [Europe PMC] [Abstract]

"Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function."
PLoS ONE 3:E3377-E3377(2008) [PubMed] [Europe PMC] [Abstract]

"The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans."
J. Exp. Med. 206:1495-1503(2009) [PubMed] [Europe PMC] [Abstract]

"Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6."
J. Exp. Med. 208:703-714(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site."
Proc. Natl. Acad. Sci. U.S.A. 108:6223-6228(2011) [PubMed] [Europe PMC] [Abstract]