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Interleukin 6 Receptor (IL6R)

CD126; gp80; IL6R; IL-6R-1; IL-6R-Alpha; IL6RA; IL-6 receptor subunit alpha; Membrane glycoprotein 80

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. In melanocytic cells IL6R gene expression may be regulated by MITF.

The IL6 receptor is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Hu01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Hu01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Hu01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Hu01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Hu01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Mu01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Mu01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Mu01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Mu01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Mu01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Ra01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Ra01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Ra01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Ra01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Ra01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Ca01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Ca01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Ca01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Ca01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Ca01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Po01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Po01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Po01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Po01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Po01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Bo01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Bo01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Bo01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Bo01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Bo01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Rb01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Rb01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Rb01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Rb01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Rb01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV026Mo01 Recombinant Interleukin 6 Receptor (IL6R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV026Mo01 Monoclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IP.
PAV026Mo01 Polyclonal Antibody to Interleukin 6 Receptor (IL6R) WB; IHC; ICC; IF.
Assay Kits CLV026Mo01 CLIA Kit for Interleukin 6 Receptor (IL6R) CLIA assay for Antigen Detection
ELV026Mo01 ELISA Kit for Interleukin 6 Receptor (IL6R) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor."
Science 241:825-828(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular structure of interleukin 6 receptor."
Proc. Jpn. Acad., B, Phys. Biol. Sci. 64:209-211(1988)

"Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells."
Biochem. J. 277:659-664(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism."
Eur. J. Immunol. 24:1945-1948(1994) [PubMed] [Europe PMC] [Abstract]

"Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor."
J. Biol. Chem. 274:7207-7215(1999) [PubMed] [Europe PMC] [Abstract]

"Soluble cytokine receptors are present in normal human urine."
J. Exp. Med. 170:1409-1414(1989) [PubMed] [Europe PMC] [Abstract]

"Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130."
EMBO J. 12:1705-1712(1993) [PubMed] [Europe PMC] [Abstract]

"The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells."
J. Cell Sci. 113:3593-3602(2000) [PubMed] [Europe PMC] [Abstract]

"Increased association with detergent-resistant membranes/lipid rafts of apically targeted mutants of the interleukin-6 receptor gp80."
Eur. J. Cell Biol. 84:819-831(2005) [PubMed] [Europe PMC] [Abstract]

"Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain."
Proc. Natl. Acad. Sci. U.S.A. 99:15959-15964(2002) [PubMed] [Europe PMC] [Abstract]

"Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."
Science 300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]

"Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels."
Am. J. Hum. Genet. 80:716-726(2007) [PubMed] [Europe PMC] [Abstract]