Call Now

Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)

Flt1; Fms-Related Tyrosine Kinase 1; Vascular Permeability Factor Receptor; Fms-like tyrosine kinase 1; Tyrosine-protein kinase receptor FLT

Vascular endothelial growth factor receptor-1 was originally discovered through the screening of a human placental cDNA library . It is a receptor tyrosine kinase (RTK) specific for the angiogenic factors VEGF (VEGF-A), PlGF, and VEGF-B. VEGF R1 is expressed in two forms via alternate splicing at the pre-mRNA level: a full-length, membrane bound receptor capable of transducing signal, and a truncated, soluble receptor (sVEGF R1) capable of sequestering ligand or dimerizing with full-length receptor and preventing signal transduction.

Although VEGF R1 null mutations are lethal, deletions of the kinase domain are not, suggesting that the soluble form, or at least the extracellular domain, is all that is necessary for normal vascular development.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Hu01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Hu01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Hu01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Hu01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Hu01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Mu01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Mu01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Mu01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Mu01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Mu01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Ra01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Ra01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Ra01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Ra01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Ra01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Ca01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Ca01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Ca01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Ca01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Ca01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Po01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Po01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Po01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Po01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Po01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Bo01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Bo01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Bo01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Bo01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Bo01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Rb01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Rb01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Rb01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Rb01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Rb01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV023Mo01 Recombinant Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV023Mo01 Monoclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IP.
PAV023Mo01 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) WB; IHC; ICC; IF.
Assay Kits CLV023Mo01 CLIA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) CLIA assay for Antigen Detection
ELV023Mo01 ELISA Kit for Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family."
Oncogene 5:519-524(1990) [PubMed] [Europe PMC] [Abstract]

"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor."
Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of the VEGF binding site on the Flt-1 receptor."
Biochem. Biophys. Res. Commun. 262:731-738(1999) [PubMed] [Europe PMC] [Abstract]

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

"A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia."
Circ. Res. 102:1566-1574(2008) [PubMed] [Europe PMC] [Abstract]

"A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells."
J. Cell. Biochem. 110:732-742(2010) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13."
Jpn. J. Cancer Res. 78:655-661(1987) [PubMed] [Europe PMC] [Abstract]

"Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules."
J. Biol. Chem. 273:23410-23418(1998) [PubMed] [Europe PMC] [Abstract]

"A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF."
Oncogene 10:135-147(1995) [PubMed] [Europe PMC] [Abstract]

"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1."
Blood 87:3336-3343(1996) [PubMed] [Europe PMC] [Abstract]

"The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma."
Biochem. Biophys. Res. Commun. 238:487-491(1997) [PubMed] [Europe PMC] [Abstract]

"Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."
Biochem. Biophys. Res. Commun. 246:95-99(1998) [PubMed] [Europe PMC] [Abstract]

"Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells."
Am. J. Pathol. 158:265-273(2001) [PubMed] [Europe PMC] [Abstract]

"Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding."
Biochem. J. 358:465-472(2001) [PubMed] [Europe PMC] [Abstract]

"Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor."
Growth Factors 19:193-206(2001) [PubMed] [Europe PMC] [Abstract]

"Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers."
Int. J. Biochem. Cell Biol. 33:315-324(2001) [PubMed] [Europe PMC] [Abstract]

"Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells."
Diabetes 52:2959-2968(2003) [PubMed] [Europe PMC] [Abstract]

"Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1."
Nat. Med. 9:936-943(2003) [PubMed] [Europe PMC] [Abstract]

"The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)."
FASEB J. 18:929-931(2004) [PubMed] [Europe PMC] [Abstract]

"Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells."
Oncogene 24:2647-2653(2005) [PubMed] [Europe PMC] [Abstract]

"Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases."
Br. J. Cancer 94:1710-1717(2006) [PubMed] [Europe PMC] [Abstract]

"A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1."
J. Biol. Chem. 281:867-875(2006) [PubMed] [Europe PMC] [Abstract]

"The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes."
Arterioscler. Thromb. Vasc. Biol. 28:322-328(2008) [PubMed] [Europe PMC] [Abstract]

"Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt."
Circ. Res. 103:261-268(2008) [PubMed] [Europe PMC] [Abstract]

"Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement."
Br. J. Cancer 103:82-89(2010) [PubMed] [Europe PMC] [Abstract]

"RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway."
J. Biol. Chem. 286:9097-9106(2011) [PubMed] [Europe PMC] [Abstract]

"gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1."
J. Biol. Chem. 286:42514-42523(2011) [PubMed] [Europe PMC] [Abstract]

"Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis."
Vasc. Cell 3:15-15(2011) [PubMed] [Europe PMC] [Abstract]

"Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis."
J. Biochem. Mol. Biol. 39:469-478(2006) [PubMed] [Europe PMC] [Abstract]

"VEGF receptor protein-tyrosine kinases: structure and regulation."
Biochem. Biophys. Res. Commun. 375:287-291(2008) [PubMed] [Europe PMC] [Abstract]

"VEGFs and receptors involved in angiogenesis versus lymphangiogenesis."
Curr. Opin. Cell Biol. 21:154-165(2009) [PubMed] [Europe PMC] [Abstract]

"Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling."
Biochim. Biophys. Acta 1804:567-580(2010) [PubMed] [Europe PMC] [Abstract]

"Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1)."
Cancer 116:1027-1032(2010) [PubMed] [Europe PMC] [Abstract]

"Signal transduction by vascular endothelial growth factor receptors."
Biochem. J. 437:169-183(2011) [PubMed] [Europe PMC] [Abstract]

"Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia."
Proc. Jpn. Acad., B, Phys. Biol. Sci. 87:167-178(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor."
Cell 91:695-704(1997) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states."
J. Mol. Biol. 293:531-544(1999) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1."
J. Biol. Chem. 279:10382-10388(2004) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity."
J. Biol. Chem. 285:23779-23789(2010) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]